PREPARATION OF SUSTAINED-RELEASE TIABROFENIC ACID BEADS

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İstanbul Journal of Pharmacy
Volume:34 Issue:2
PREPARATION OF SUSTAINED-RELEASE TIABROFENIC ACID BEADS

PREPARATION OF SUSTAINED-RELEASE TIABROFENIC ACID BEADS

Authors : A Yildiz, D Sensoy, A Baytokova, Y OZSOY, A ARAMAN

Pages : 0-0

View : 104 | Download : 11

Publication Date : 2015-09-08

Article Type : Research Paper

Abstract :Tiaprofenic acid insert ignore into journalissuearticles values(TA);, has analgesic, anti-inflammatory and antipyretic properties; it is an inhibitor of prostaglandin synthetase. The usual oral dose by mouth is 600 mg daily; this may be given in 2 or 3 divided doses or once daily as a sustained-release preparation. TA is readily absorbed from the gastrointestinal tract. It has a short half-life of about 2 hours. Sodium alginate is a natural, biodegradable and biocornpatible polymer used as suspending and gelling agent in pharmaceutical technology. Recently, the alginate gel beads has received much attention in sustained-release preparation. The aim of the present study was to formulate sustained-release TA beads based on sodium alginate in order to reduce daily dose and to minimize gastrointestinal disturbance caused by the drug. Key words: Tiaprofenic acid, sustained-release beads, sodium alginate.
Keywords : Tiaprofenic acid, sustained release beads, sodium alginate

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