THE EVALUATION OF TURKISH AUTUMN FLOWERING COLCHICUM SPECIES

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İstanbul Journal of Pharmacy
Volume:32
THE EVALUATION OF TURKISH AUTUMN FLOWERING COLCHICUM SPECIES

THE EVALUATION OF TURKISH AUTUMN FLOWERING COLCHICUM SPECIES

Authors : N SÜTLÜPINAR

Pages : 1-8

View : 47 | Download : 10

Publication Date : 2015-09-09

Article Type : Research Paper

Abstract :65 Colchicum species grow all over the World and 25 of them grow in Turkey. In this work, Turkish Colchicum species with respect to the tropolone alkaloids that have gained importance in pharmaceutical industry have been evaluated. First of all, the preparative TLC separation and spectrophotometric determination of colchicine and demecolcine were accomplished. Species with low alkaloid content and with small seeds and corms which have not economic value were eliminated and 10 Colchicum species were investigated with respect to their total tropolonic alkaloid content using a direct spectrophotometric method. HPLC was also used to quantitate the amount of colchicine, colchicoside and demecolcine. The results obtained were compared with those of C.autumnale cited in the Pharmacopeiae. As a result of our investigations, alkaloid content of C.baytopiol-urn, bivonae, bol-nmuelleri, cilicicum, kotschyi and speciosum species were found as rich as or even richer than C.autumnale. Key words: Colchicum, Colchicine, Colchicoside, Demecolcine, Tropo- Ionic Alkaloids.
Keywords : Colchicum, Colchicine, Colchicoside, Demecolcine, TropoI lonic Alkaloids

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