Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

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İstanbul Journal of Pharmacy
Volume:51 Issue:1
Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

Authors : Sinem ŞAHİN, Burcu MESUT, M Ezgi DURGUN, Esher ÖZÇELİK, Yıldız ÖZSOY

Pages : 26-34

View : 30 | Download : 7

Publication Date : 2021-04-30

Article Type : Research Paper

Abstract :Background and Aims: The study aimed to design a Fixed-dose tablet formulation of Metformine and Repaglinide. Methods: Wet granulation method was used to prepare tablet formulations. Characterization studies and dissolution studies were performed. Results: A stable formulation was developed according to the requirements of the pharmacopoeia criteria. This new formulsation dissolution results showed that Repaglinide and Metformin HCl dissolved more than 85% from film tablets at 15 minutes. Conclusion: Thus, an alternative product to the market product was developed.
Keywords : Fixed Dose Tablet, Metformin, Repaglinide

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