Curcumin prevents tenofovir/lamivudine/efavirenzinduced nephrotoxicity in rats

Authors : Elias ADIKWU, Ruth O OWOTA, Innocent BİRADEE

Pages : 221-227

View : 44 | Download : 8

Publication Date : 2021-08-31

Article Type : Research Paper

Abstract :Background and Aims: Nephrotoxicity is an adverse effect, which may occur with the use of tenofovir/lamivudine/efavirenz insert ignore into journalissuearticles values(TLE); in the treatment of human immune deficiency virus insert ignore into journalissuearticles values(HIV); infection. Curcumin insert ignore into journalissuearticles values(CUM);, an isolate of Curcuma longa L. is used in folk medicine for the treatment of ailments. This study attempts to establish whether CUM supplementation can protect against a rat model of TLE-induced nephrotoxicity. Materials and Methods: Adult male Wistar rats insert ignore into journalissuearticles values(n=40); were randomly grouped and supplemented orally with CUM insert ignore into journalissuearticles values(50, 100 and 200 mg/kg/day); prior to the oral administration of TLE insert ignore into journalissuearticles values(300/300/600 mg/kg/day); for 30 days. After the treatment, the rats were fasted overnight, weighed and anesthetized. Blood samples were collected, and sera were extracted for biochemical analyses. Kidney samples were excised, weighed and processed for oxidative stress markers and histology. Results: Body weight was decreased insert ignore into journalissuearticles values(p<0.01); whereas kidney weight was increased insert ignore into journalissuearticles values(p<0.01); in TLE administered rats when compared to the control. Significant insert ignore into journalissuearticles values(p<0.001); increments in serum uric acid, creatinine, urea and kidney malondialdehyde levels were observed in TLE-administered rats. Significant insert ignore into journalissuearticles values(p<0.001); decreases in serum total protein, albumin, electrolytes, kidney superoxide dismutase, glutathione, catalase and glutathione peroxidase levels were observed in TLE administered rats when compared to the control. TLE produced tubular necrosis and hypercellular glomerulus with mesangial proliferation in the kidneys of treated rats. However, CUM insert ignore into journalissuearticles values(50, 100 and 200 mg/kg); supplementation abrogates TLE-induced nephrotoxicity in a dose-related manner at p<0.05, p<0.01 and p<0.001, respectively, when compared to TLE group. Conclusion: CUM seems effective against TLE-induced nephrotoxicity.
Keywords : Antiretroviral, curcumin, nephrotoxicity, rat

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