Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens*

Authors : Müjgan ÖZFENERCİ, Elif Burcu BALİ, Demet ERDÖNMEZ, Ufuk KOCA ÇALIŞKAN

Pages : 54-63

Doi:10.26650/IstanbulJPharm.2022.998774

View : 53 | Download : 10

Publication Date : 2022-04-28

Article Type : Research Paper

Abstract :Background and Aims: Aromatherapy, as one of the complementary therapies, uses essential oils as the main therapeutic agents to treat several diseases. In the present study, it was aimed to investigate inhibition of quorum sensing insert ignore into journalissuearticles values(QS); and bio- film formation of aromatherapeutic essential oils insert ignore into journalissuearticles values(AEOs); and their pharmaceutical combinations insert ignore into journalissuearticles values(PC-I and PC-II);. Methods: The anti-QS potential of AEOs were determined using the biosensor strains Chromobacterium violaceum ATCC 12472 and Pseudomonas aeruginosa PAO1. Anti-QS activity was detected by agar-well diffusion and violacein pigment inhi- bition assays. Blocking of PAO1 swim and swarm motilities and biofilm formation was also performed. Results: Most of the AEOs demonstrated highly active insert ignore into journalissuearticles values(>95%); violacein pigment inhibition. Additionally, they inhibited swarming insert ignore into journalissuearticles values(40.34%-72.80%); and swimming insert ignore into journalissuearticles values(20.06%-50.08%); motilities of PAO1. Moreover, the majority of AEOs also de- creased the biofilm formation, particularly on P. aeruginosa and S. aureus. Conclusion: Consequently, aromatherapeutic formulations might be a complementary or prophylactic cure for infectious dis- ease by their anti-QS and antibiofilm activities rather than just antimicrobial effects.
Keywords : Aromatherapeutic essential oils, Antibiofilm, Quorum sensing, Pseudomonas aeruginosa PAO1, Synergistic effect

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