Antioxidant and prooxidant properties of selected herbs and Citrus bergamia Risso et Poiteau (bergamot) used for the management of hyperlipidemia

Authors : Zehra İlke AKYILDIZ, Fadime AYDIN KÖSE, Nehir UNVER SOMER

Pages : 156-163

Doi:10.26650/IstanbulJPharm.2022.1001613

View : 103 | Download : 10

Publication Date : 2022-08-30

Article Type : Research Paper

Abstract :Background and Aims: In recent years, there has been an increased interest in the search for herbs to aid the management of hyperlipidemia. There is currently very little data on the simultaneous evaluation of the antioxidant and prooxidant properties of antihyperlipidemic herbs. This study was designed to evaluate the antioxidant and prooxidant properties of four antihyper- lipidemic herbal drugs and also of bergamot. Methods: Antioxidant property was determined by ferric ions insert ignore into journalissuearticles values(Fe3+); reducing capacity insert ignore into journalissuearticles values(IRC);, DPPH radical scavenging ac- tivity insert ignore into journalissuearticles values(DPPH IC50); and trolox equivalent antioxidant capacity insert ignore into journalissuearticles values(TEAC);; deoxyribose degradation test was used for prooxidant property. Results: The highest total phenolic content insert ignore into journalissuearticles values(TPC); was in the myrtle leaf insert ignore into journalissuearticles values(ML);insert ignore into journalissuearticles values(135.35±3.46 mg GAE/g, p<0.05); whereas the highest total flavonoid content insert ignore into journalissuearticles values(TFC); was in green tea insert ignore into journalissuearticles values(GT); insert ignore into journalissuearticles values(48.76±0.69 mg QE/g, p<0.05); both of which were main- tained from a pharmacy. Among the bergamot samples, the highest TPC and TFC values were in filtered fruit juice insert ignore into journalissuearticles values(BFFJ); as 197.35±6.29 mg GAE/100 mL; and 94.14±1.39 mg QE/100 mL; p<0.05, respectively. GT showed the highest antioxidant capac- ity in IRC and TEAC assays insert ignore into journalissuearticles values(2.29±0.12 mM TE/g; and 2.32±0.07 mmol TE/mg, p<0.05);. The lowest DPPH IC50 was identified in ML from a pharmacy insert ignore into journalissuearticles values(6.95±0.08 µg/mL; p<0.01);. BFFJ had the highest IRC insert ignore into journalissuearticles values(2.94±0.031 mM TE/10µL);, TEAC insert ignore into journalissuearticles values(5.14±0.084 mmol TE/10 µL); and the lowest DPPH IC50 value insert ignore into journalissuearticles values(10.561±0.17 µL);. GT from a pharmacy and 1mg/mL concentration BFLFJ insert ignore into journalissuearticles values(fil- tered and lyophilized); were associated with the lowest hydroxyl radical scavenger activity insert ignore into journalissuearticles values(0.171±0.013 µM MDA equivalent, p<0.05 and 0.144±0.015 µM MDA equivalent, p<0.05);. Conclusion: BFLFJ and GT got the highest attention due to high TPC, TFC, antioxidant and low prooxidant properties. Our results highlight the necessity of clarifying the value of bergamot and GT in this field with further studies.
Keywords : Antioxidant, Bergamot, Citrus bergamia, Medicinal plants, Oxidative stress, Prooxidant

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