Relationship of thiol/disulphide homeostasis with oxidative stress parameters in non-diabetic, prediabetic and type 2 diabetic Turkish women

Authors : Ayse Ceylan HAMAMCIOGLU, Çınar SEVERCAN, Taner BAYRAKTAROĞLU
Pages : 121-128
Doi:10.26650/IstanbulJPharm.2022.1011516
View : 46 | Download : 14
Publication Date : 2022-08-30
Article Type : Research Paper
Abstract :Background and Aims: Deterioration of thiol/disulphide homeostasis insert ignore into journalissuearticles values(TDH); is found in several diseases, including diabetes. This study aimed to examine the association between TDH and oxidative stress parameters in nondiabetics, prediabetics and newly diagnosed type 2 diabetics. Methods: A total of 26 non-diabetic, 24 prediabetic and 19 type 2 diabetic women were involved in our study. They all applied to Zonguldak Bulent Ecevit University, Health Practice and Research Center, Endocrinology and Metabolism Diseases, Diabe- tes Polyclinic to be tested for type 2 diabetes mellitus. The demographic and laboratory data were collected from the patient files. Oxidative stress parameters and dynamic TDH were investigated using ELISA kits. Results: Total oxidant status insert ignore into journalissuearticles values(TOS);, total thiol and disulphide levels were significantly higher in type 2 diabetics than the non-diabetics insert ignore into journalissuearticles values(24.24±14.93 versus 14.14±12.19, 646.47±75.51 versus 470.88±180.85, and 179.32±51.24 versus 91.85±40.29, respectively);. In type 2 diabetics, a positive correlation between TOS and native thiol, total thiol and disulphide levels was found insert ignore into journalissuearticles values(P=0.000);. In prediabetics, a significant positive correlation was found between total antioxidant capacity and total thiol levels insert ignore into journalissuearticles values(P<0.05);, and also between arylesterase and native and total thiol levels insert ignore into journalissuearticles values(P<0.05);. Conclusion: The elevation of oxidative stress and the deterioration of TDH might cause the formation of symptoms related to high blood glucose levels in type 2 diabetics.
Keywords : Sulfhydryl compounds, Diabetes mellitus, Prediabetic state, Oxidative stress

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