Antioxidants prevent indomethacin-induced oxidative damage in tongue tissues of rats

Authors : İsmet Burcu TURKYİLMAZ, Refiye YANARDAĞ

Pages : 73-79

View : 56 | Download : 101

Publication Date : 2023-04-28

Article Type : Research Paper

Abstract :Background and Aims: Indomethacin insert ignore into journalissuearticles values(Indo); is an important nonsteroidal anti-inflammatory drug that has beneficial effects as a pain killer, but also has side effects. In this study, the protective effects of vitamins, selenium and ranitidine insert ignore into journalissuearticles values(Ran); against the side effects of Indo on tongue tissue were investigated. Methods: Rats were divided into six groups: the control group as group I; the group given a vitamin-selenium insert ignore into journalissuearticles values(Vitamin C, 100 mg/kg; Vitamin E, 100 mg/kg, beta carotene, 15 mg/kg, selenium, 0.2 mg/kg); combination as group II; the group treated with Indo as group III; the group administered vitamins-selenium and Indo insert ignore into journalissuearticles values(25 mg/kg, single dose); as group IV; the group given Ran insert ignore into journalissuearticles values(150 mg/kg); as group V; and the group given Ran and Indo as group VI. The experiments were done for 3 days. Animals received vitamins-selenium and Ran for 3 days, 2 h before the Indo administration insert ignore into journalissuearticles values(in same dose and time);. Tongue tissues were taken and homogenized. Results: In the supernatants, glutathione levels, superoxide dismutase, catalase and glutathione-dependent enzyme activi- ties were reduced. Protein carbonyl, lipid peroxidation levels, lactate dehydrogenase and myeloperoxidase activities were increased in the group that was given Indo. Administration of vitamins-selenium and Ran reversed the levels and activities of the tested parameter in the Indo group. Conclusion: We suggest that vitamins, selenium and Ran have powerful protective effects on Indo-induced tongue injury in rats.
Keywords : Beta carotene, Vitamin C, Vitamin E, Indomethacin, Lingual Tissue, Selenium

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