Electrochemical behavior and differential pulse voltammetric determination of budesonide in suspension ampoules

Authors : Orkhan YOLCHUYEV, Zeynep AYDOĞMUŞ

Pages : 150-158

Doi:10.26650/IstanbulJPharm.2023.1093821

View : 49 | Download : 33

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :Background and Aims: Budesonide insert ignore into journalissuearticles values(BUD); is a broad-spectrum anti-inflammatory and anti-allergic glucocorticosteroid agent. It is used in the treatment of chronic obstructive pulmonary disease insert ignore into journalissuearticles values(COPD);, Crohn\`s disease, and ulcerative colitis. The aim of the study was to investigate the electrochemical properties of BUD for the first time and to develop a sensitive, easy, and selective new differential pulse voltammetry insert ignore into journalissuearticles values(DPV); method for its determination in drug formulation. Methods: The electrochemical behavior of BUD was investigated using cyclic voltammetry insert ignore into journalissuearticles values(CV); and differential pulse voltammetry insert ignore into journalissuearticles values(DPV); with a carbon paste electrode insert ignore into journalissuearticles values(CPE); in various electrolyte and buffer solutions with pH ranging from 2 to 9. An irreversible, well-defined reduction current peak of about -859 mV was obtained. A DPV method was developed and validated for the determination of BUD in suspension ampoules using a CPE electrode in a 0.1 M HCl electrolyte solution containing 13% KCl and 8% methanol. Results: The cathodic peak was found to be adsorption-controlled. The calibration curve was linear between 1.65- 35.35 µg/ml. The limit of detection insert ignore into journalissuearticles values(LOD); and limit of quantification insert ignore into journalissuearticles values(LOQ); values were found to be 0.52 µg/mL and 1.57 µg/mL, respectively. The developed method offered an effective capability for the determination of BUD in suspension ampoules, with a recovery rate of 98.47%. Conclusion: The DPV method developed in this study could be used for routine quantitative analysis of BUD in pharmaceutical preparations due to its fast, accurate, inexpensive, and environmentally friendly nature.
Keywords : Budesonide, determination, pharmaceutical preparation, validation, voltammetry

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