The Effects of Dipeptidyl Peptidase-4 Inhibitors on Kidney Function in Advanced CKD

Authors : Mahmud Islam, Ahmed Cihad Genç

Pages : 166-173

Doi:10.34084/bshr.1347133

View : 97 | Download : 75

Publication Date : 2023-10-25

Article Type : Research Paper

Abstract :Objective: This study aimed to investigate the effects of DPP-4 inhibitors on kidney function in type 2 diabetes mellitus patients with stages 3-5 chronic kidney disease, focusing on estimated glomerular filtration rate and proteinuria. Methods: This is a retrospective case-control design, and data were collected from a single hospital\'s software and the Turkish Ministry of Health\'s National Data Tracking System. Diabetic patients with T2DM and CKD stages 3-5 were included, with dipeptidyl peptidase-4 inhibitor users (n=118) and non-users (n=48) forming the intervention and control groups, respectively. Baseline demographics, clinical characteristics, and outcomes were compared between groups. Results: At baseline, both groups demonstrated similar age, gender distribution, body mass index, and eGFR. Over a 12-month follow-up, while slight improvements in eGFR were observed in the intervention group and minor reductions in the control group, these changes did not reach statistical significance (p>0.05). Proteinuria showed a stable trend in the intervention group, whereas a significant increase was noted in the control group (p=0.035). Age significantly correlated with eGFR (p<0.001) but not proteinuria (p=0.156). The study found that DPP-4 inhibitor users experienced a statistically significant reduction in HbA1c levels (p=0.041) compared to minimal changes in the control group. Conclusion: The study suggests potential renoprotective effects of DPP-4 inhibitors in T2DM patients with advanced CKD, as evidenced by trends in eGFR and proteinuria stabilization.
Keywords : DPP 4 inhibitörleri, kronik böbrek hastalığı, proteinüri, tahmini glomerüler filtasyon hızı, tip 2 DM

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