Antimicrobial Efficacy of Some Products with Propolis Hydroalcoholic Extract 30% and Antiviral Synthesis

Authors : Carmen Violeta POPESCU, Hazem ABBAS, Stefan MANEA, Lili IVOPOL, Alina DUNE, Candice POPINIUC, Dumitru LUPULEASA

Pages : 70-70

View : 82 | Download : 9

Publication Date : 2018-12-08

Article Type : Conference Paper

Abstract :The aim: The purpose of this study is to verify and prove antimicrobial efficacy of two topical pharmaceutical finished products, a gel and a cream, with propolis hydro alcoholic extract 30% 1 and an antiviral synthesis used as active pharmaceuticals ingredients. These products are intended especially in the treatment of herpes or any of a group of viral diseases caused by herpes viruses, affecting the skin insert ignore into journalissuearticles values(often with blisters);. Methods and Materials: The study of antimicrobial efficacy was performed in accordance with the provisions of the European Pharmacopoeia, 9th edition, version in force, method described in Chapter 5.1.3. Efficacy of antimicrobial preservation and acceptance criteria for preparations for cutaneous use 2 and the specialty literature. The sample under study was forcedly contaminated with suspensions insert ignore into journalissuearticles values(10 5 /mL); of Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus brasiliensis and the times studied were 0, 2, 7, 14, 21, 28 days. Results: Acceptance criteria for antimicrobial efficacy are presented as a logarithmic reduction in the number of viable microorganisms, calculate the ratio between the number of UFC/ mL from baseline insert ignore into journalissuearticles values(T 0 ); and the number of UFC/ mL determined for each test time and have been fully met. Conclusions: The pharmacopoeia requirements were entirely met for the gel product, and the cream did not prove efficacy on the Candida albicans microorganism.
Keywords : Antimicrobial Efficacy, Hydroalcoholic Extract, Propolis

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