A Three Year Retrospective Analysis Of Anti-Tnf Treatment Outcomes In Rheumatoid Arthritis And Ankylosing Spondylitis Patients

Dilek TEZCAN; Seyfettin ÜSTÜNSOY; Göksal KESKİN; İrem BİLGETEKİN

doi:10.16899/jcm.645326

A Three Year Retrospective Analysis Of Anti-Tnf Treatment Outcomes In Rheumatoid Arthritis And Ankylosing Spondylitis Patients

Authors : Dilek TEZCAN, Seyfettin ÜSTÜNSOY, Göksal KESKİN, İrem BİLGETEKİN

Pages : 324-330

Doi:10.16899/jcm.645326

View : 41 | Download : 14

Publication Date : 2020-09-30

Article Type : Research Paper

Abstract :Abstract Background/Aims: T o investigate the effectiveness and reliability of anti-TNF treatment in Ankylosing Spondylitis-Rheumatoid arthritis patients. Methods: 180 patients insert ignore into journalissuearticles values( 110 Rheumatoid arthritis insert ignore into journalissuearticles values(RA); patients diagnosed according to 1987 American Rheumatism Association criteria, 70 Ankylosing Spondylitis insert ignore into journalissuearticles values(AS); patients diagnosed according to Modified NewYork Criteria); admitted to the hospital for arthritis and related compliants who were followed up and treated with anti-TNF treatment in the department of Rheumatology&Immunology from 2009 to 2011. We enrolled 100 patients with RA insert ignore into journalissuearticles values(76 women, 24 men); and 60 patients with AS insert ignore into journalissuearticles values(16 women, 44 men); to the study, excluded 20 patients according to the exclusion criterias. The response of the patients to the anti-TNF treatment was evaluated by comparing the clinical parameters BASDAI, DAS28 and VAS score; and laboratory measurements of erytrocyte sedimentation rate, C-reactive protein levels of rheumatoid arthritis and ankylosing spondylitis before and six months after the treatment. Results: After the six months of anti Tnf treatment , BASDAI score for AS, DAS28 score for RA, VAS, ESR and CRP levels for both diseases showed a statistically significant improvement, moreover it was determined that demographic variations did not affect these values. Conclusions: Our results demonstrated that anti-TNF treatment is safe and effective treatment modality in patients with Ankylosing Spondylitis and Rheumatoid arthritis. These findings are short-term results of a study, and therefore future studies with larger patient series and long term follow-up are needed to look at outcomes of long term therapies.
Keywords : ankylosing spondylitis, rheumatoid arthritis, anti TNF treatment, outcomes

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