Evaluation of serum nitric oxide level and its relationship with disease activity parameters in patients with rheumatoid arthritis

Authors : Hülya DEVECİ, Zeliha Cansel ÖZMEN

Pages : 297-301

Doi:10.16899/jcm.769098

View : 38 | Download : 6

Publication Date : 2020-09-30

Article Type : Research Paper

Abstract :Aim: Nitric oxide insert ignore into journalissuearticles values(NO); is a molecule known to play a role in many physiological and pathological events in the body. It is thought to play an active role in inflammation. Rheumatoid arthritis insert ignore into journalissuearticles values(RA); is the most common chronic inflammatory autoimmune disease worldwide. In this study, we aimed to evaluate the serum NO levels of RA patients and their relation with parameters that are indicators of disease activity. Material and Method: Thirty patients with RA insert ignore into journalissuearticles values(7 males/ 23 females, mean age 48.80±7.88 years old); and 30 healthy control groups were included in the study. Both groups were compared with erythrocyte sedimentation rate insert ignore into journalissuearticles values(ESR);, C-reactive protein insert ignore into journalissuearticles values(CRP);, rheumatoid factor insert ignore into journalissuearticles values(RF);, anti cyclic citrullinated peptide antibody insert ignore into journalissuearticles values(anti CCP); and serum NO levels and clinically with Visual Analog Scale insert ignore into journalissuearticles values(VAS);, Disease Activity Score-28 insert ignore into journalissuearticles values(DAS-28); and Health Assessment Questionnaire insert ignore into journalissuearticles values(HAQ); scales. Results: ESR, CRP and NO levels in the patient group were significantly higher than the control group insert ignore into journalissuearticles values(p 3.2, inactive disease DAS-28 <3.2); according to DAS-28 scores, there was no significant difference in serum NO levels between the two groups. Serum NO levels of the patient group were not correlated with clinical insert ignore into journalissuearticles values(VAS, DAS-28); and laboratory markers insert ignore into journalissuearticles values(ESR, CRP, RF, Anti CCP); of disease activity. Conclusion: In this study, we found that serum NO levels in RA patients increased significantly compared to the healthy control group. However, increased serum NO levels in RA patients were not associated with laboratory and clinical disease activity parameters.
Keywords : Nitric oxide, Rheumatoid arthritis, Disease Activity Score 28 DAS 28, Health Assessment Questionnaire HAQ,

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