THE CONTRIBUTION OF DIFFUSION TENSOR IMAGING TO CONVENTIONAL MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS PATIENTS

Authors : Gülay MAÇİN, Fuldem YILDIRIM DÖNMEZ, Eda DERLE, Ülkü Sibel BENLİ, A Muhtesem AGILDERE
Pages : 170-175
Doi:10.16899/jcm.1213743
View : 90 | Download : 10
Publication Date : 2023-03-22
Article Type : Research Paper
Abstract :Aim: The aim of this study is to investigate whether anisotropic diffusion is superior to conventional magnetic resonance imaging for understanding the pathophysiology of multiple sclerosis insert ignore into journalissuearticles values(MS); disease by Fractional anisotropy insert ignore into journalissuearticles values(FA); measurements. Material and Methods: In our study, FA measurements were made from the plaque, the periplaque area, the normal appeared white matter contralateral to the plaque and normal appearing white matter areas in MS patients and from the normal white matter in the control group. 3D trography maps were made in all MS patients and it was evaluated whether white pathways were affected by MS disease. Results: When the degree of anisotropy was compared to the control group, the degree of plaques was found lowest. Increase was observed in periplaque, the normal appeared white matter contralateral to the plaque and normal appearing white matter, respectively. The active plaque FA value was found to be lower than the chronic plaque FA value, and the chronic plaque FA was found to be lower than the normal white matter FA value. It has been shown that plaques traced along axonal pathways in MS patients cause interruption in axonal pathways. Conclusion: Progressive decrease in anisotropy from normal appearing white matter to periplaque white matter and plaque level indicates myelin damage. This suggests that the white matter that appears normal on T2 images on conventional MR is not actually normal. Based on these results, it was thought that diffusion tensor imaging would be useful in evaluating the burden of disease in MS patients.
Keywords : Multiple Sclerosis, Diffusion Tensor Imaging, Fractional Anisotropy, Magnetic Resonance Imaging

ORIGINAL ARTICLE URL