Does Platelet Distribution Width Correlate with Acute Coronary Syndrome Severity and Coronary Thrombus Burden?

Authors : Hızır OKUYAN
Pages : 682-685
Doi:10.16899/jcm.1190001
View : 68 | Download : 57
Publication Date : 2023-07-31
Article Type : Research Paper
Abstract :Aim: Platelets play a pivotal role in the pathogenesis of acute coronary syndrome insert ignore into journalissuearticles values(ACS);, and platelet distribution width insert ignore into journalissuearticles values(PDW); shows the activities of platelets in circulation. The purpose of this study was to determine the association of PDW with the ACS severity and angiographic intracoronary thrombus burden and Thrombolysis In Myocardial Infarction insert ignore into journalissuearticles values(TIMI); flow grade. Materials and Methods: One hundred forty-nine consecutive patients who were diagnosed as having ACS were retrospectively evaluated. Global Registry of Acute Coronary Events insert ignore into journalissuearticles values(GRACE); scores were calculated from the clinical and laboratory data for ACS severity. TIMI flow grades and thrombus grades of the culprit coronary arteries were calculated for each patient. Patients were grouped into two groups according to their PDW values: high PDW and low PDW. The SPSS 17.0 software was used for statistical analysis. Results: PDW was found to be correlated with GRACE scores insert ignore into journalissuearticles values(P<0.01);. The high PDW group had higher GRACE scores insert ignore into journalissuearticles values(139 vs. 126, p<0.05);. Lower TIMI flow grades insert ignore into journalissuearticles values(0 and 1); were seen in the high PDW group insert ignore into journalissuearticles values(39 vs. 33, p<0.05);. No association between intracoronary thrombus load and PDW was found in our study insert ignore into journalissuearticles values(p=0.082);. Conclusion: In our study, patients with higher PDW levels were older and had higher GRACE scores and lower TIMI flow grades. PDW levels correlate with the ACS severity and TIMI flow grade.
Keywords : Trombosit dağılım genişliği, koroner trombüs, TIMI akışı, akut koroner sendrom

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