Evaluation of urine cotinine levels in children with chronic cough

Authors : Yesim ÖZDEMİR ATİKEL, İlknur BOSTANCI, Çiğdem ÖZDİLEKCAN, Serap ÖZMEN

Pages : 686-691

Doi:10.16899/jcm.1191361

View : 414 | Download : 91

Publication Date : 2023-07-31

Article Type : Research Paper

Abstract :Bacground: Our study was planned to reveal the objective relation between urine cotinine level and tobacco smoke exposure in children suffering from chronic cough. Methods: Between ages 5-18 years, 58 patients with chronic cough with no underlying specific cause and 54 healthy individuals were included in the study. Results: There was a statistically significant difference between urine cotinine levels of cases those who exposed and unexposed insert ignore into journalissuearticles values(based on the declaration of parents); to tobacco smoke insert ignore into journalissuearticles values(p<0, 05);. The highest mean value of cotinine insert ignore into journalissuearticles values(41.3±73.7); was detected in the cases of chronic cough group who exposed to smoke. The best “cut-off value” for discriminating exposed and unexposed group was found to be 12.15 ng/ml with ROC analysis. Smoking ratio during pregnancy has been found higher in the group with chronic cough insert ignore into journalissuearticles values(p<0, 05);.FEV1/FVC ratio was found to be lower in patients with chronic cough who are passive smokers when compared with the cases in the other groups insert ignore into journalissuearticles values(p<0,05);. Conclusions: This is the first study objectively evaluating chronic cough effect of passive smoking with urine cotinine level. Since there is a meaningful decrease in FEV1/FVC ratio, close follow up is needed especially in children diagnosed as chronic cough who are exposed to tobacco smoke.
Keywords : biyobelirteçler, çevresel tütün dumanı, çocuk, kronik öksürük, pasif içicilik, idrar kotinin düzeyi

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