Fasting alters p75NTR and AgRP mRNA expression in rat olfactory bulb and hippocampus

Authors : Diana MONGESANCHEZ, Marcelıno MONTİELHERRERA, Denısse GARCİA VİLLA, Guillermo LOPEZ, J Abraham DOMÍNGUEZAVİLA, Gustavo GONZÁLEZAGUİLAR

Pages : 1074-1084

Doi:10.37212/jcnos.1168800

View : 81 | Download : 12

Publication Date : 2023-01-31

Article Type : Research Paper

Abstract :Classic non-homeostatic structures involved in food intake regulation are reciprocally influenced by metabolic signals. Orexigenic peptides expressed in the olfactory bulb insert ignore into journalissuearticles values(OB); and hippocampus insert ignore into journalissuearticles values(HP); modulate olfactory processing and memory, respectively. Hypothalamic circuits also modulate feeding behavior by activating and releasing Agouti-related peptide insert ignore into journalissuearticles values(AgRP); in response to orexigenic signals. An adequate response to fasting requires the expression of p75 neurotrophin receptor insert ignore into journalissuearticles values(p75NTR); in AgRP neurons. The present study aimed to determine whether there is a role for p75NTR and AgRP in the OB and HP on the feeding behavior of fasted rats. A group of fasted rats insert ignore into journalissuearticles values(FG); was confronted with a decision-making paradigm in a T-maze containing a standard chow pellet insert ignore into journalissuearticles values(CP);, and the same pellet coated with a phenolic-rich avocado paste extract insert ignore into journalissuearticles values(AVO); on either end; their OB and HP were then analyzed with histological and molecular tools. FG rats had briefer feeding latencies, as compared to control rats fed ad libitum insert ignore into journalissuearticles values(median latencies: 55.4 vs 191.7 min, p = 0.032);. They also had reduced cell counts in both brain structures, as compared to satiated rats. AgRP mRNA was not expressed in the HP of either group, however, it was found in the OB. p75NTR mRNA was expressed in both brain structures of FG rats. These results suggest that contrasting metabolic states insert ignore into journalissuearticles values(fasted or satiated); motivate different feeding responses, which are influenced by p75NTR and AgRP mRNA expression in non-homeostatic food intake brain structures.
Keywords : Food intake regulation, Appetitive behavior, Avocado, p75 neurotrophin receptor, Agouti related peptide

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