Metabolic syndrome as a risk factor in contrast-induced nephropathy

Authors : Belma Özlem Tural Balsak, Şehmus Özmen, Davut Akın, Mehmet Emin Yılmaz

Pages : 476-482

Doi:10.32322/jhsm.1654419

View : 70 | Download : 74

Publication Date : 2025-05-30

Article Type : Research Paper

Abstract :Aims: The expanding use of contrast media has made contrast-induced acute kidney injury (CI-AKI) a cause of acute renal failure. This study investigated the relationship between metabolic syndrome (MS), insulin resistance, and contrast-induced acute kidney injury. Methods: This study encompassed 94 hospitalized patients (73 male) with creatinine levels of 1.0 and above who underwent contrast-enhanced computed tomography for various reasons in the internal medicine clinics of Dicle University Faculty of Medicine. Patients whose creatinine levels were routinely measured before and 48 hours after tomography and whose anamnesis information was sufficient for the International Diabetes Federation metabolic syndrome criteria were retrospectively included in the study. HOMA-IR values ​​were calculated. Results: CI-AKI developed in 10 (10.6%) patients out of 94. MS was identified in 60% of the group that developed CI-AKI and 38.1% that did not. Insulin resistance was observed in 30% of the group that developed CI-AKI and 17.9% that did not. Despite the observed difference, it did not achieve statistical significance. Considerable differences were found between the two groups regarding albumin, urea, creatinine, uric acid, C-reactive protein, and hemoglobin levels. CI-AKI was significantly more common in individuals with low creatinine clearance and in those with creatinine ≥1.3 mg/dl. Conclusion: Our study showed that a higher rate of patients with MS was detected in the group with CI-AKI. MS has been accused of being a risk factor for CI-AKI. Therefore, caution should be exercised when administering contrast to patients with MS.
Keywords : Kontrast Madde Nefropatisi, Metabolik Sendrom, İnsülin Direnci

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