Investigation of the synovial fluid pro-inflammatory cytokines and clinical findings in disc displacements of TMJ

Authors : Canay YILMAZ ASAN, Şeyma BAYINDIR, Ahmet Emin DEMİRBAŞ, Didem BARLAK KETİ, Nükhet KÜTÜK

Pages : 345-349

Doi:10.47582/jompac.1333161

View : 111 | Download : 47

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :Aims: Temporomandibular disorders insert ignore into journalissuearticles values(TMD); are common musculoskeletal disease that affects the soft tissues and bone structures of the temporomandibular joint insert ignore into journalissuearticles values(TMJ);. Inflammatory mediators play a critical role in the etiology of TMD by affecting various molecular mechanisms. This study aims to investigate the effect of pro-inflammatory cytokines on TMJ internal derangements and evaluate the relationship between clinical features. Methods: Patients who underwent arthrocentesis because of TMD were included in this study. Patients were divided into 2 groups according to anterior disc displacement with reduction insert ignore into journalissuearticles values(Group 1); and without reduction insert ignore into journalissuearticles values( Group 2);. Clinical findings before and after the arthrocentesis were evaluated retrospectively. Synovial fluid TNF-α, IL-1β, and IL-6 levels were analyzed with the ELISA method. Results: A total of 28 patients were included, with 15 patients in Group 1 and 13 patients in Group 2. All patients were female with an average age of 30.75±14.9. The average pre-operative pain score was 6.6±1.95 in all patients. After the arthrocentesis, the average pain score was 2.0 insert ignore into journalissuearticles values( 1.0 - 2.5); and the difference was significant insert ignore into journalissuearticles values(p<0.001);. Group 1 have a higher maximum mouth opening insert ignore into journalissuearticles values(MMO); than Group 2 preoperatively and the difference was statistically significant insert ignore into journalissuearticles values(p=0.013);. The difference in synovial fluid cytokine levels was not statistically significant between groups. There was no statistically significant correlation between cytokines and clinical findings. Conclusion: Arthrocentesis is beneficial for reducing joint pain in patients with TMJ internal derangements. Pro-inflammatory cytokine levels are similar in TMJs with disc displacement with and without reduction.
Keywords : Temporomandibular Eklem, TME, enflamatuar, sitokin, sinovyal sıvı

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