INVESTIGATION of ACTIVITIES ENZYME PROLIDASE (PRO) and GLUTATHIONE S-TRANSFERASE (GST) in POLYCYSTIC OVARY SYNDROME (PCOS) PATIENTS

Authors : Kazım UÇKAN, Halit DEMİR, Yusuf BAŞKIRAN, Canan DEMİR

Pages : 20-31

View : 53 | Download : 11

Publication Date : 2022-09-30

Article Type : Review Paper

Abstract :This study investigated serum antioxidant enzyme activity insert ignore into journalissuearticles values(Glutathione-S-transferase); and Prolidase in patients with PCOS. A total of 42 patients with PCOS and 43 healthy control subjects were enrolled. Serum Prolidase and Glutathione-S-transferase insert ignore into journalissuearticles values(GST); activities were measured spectrophotometrically. Age, TSH, fT4, Prolactin, Estradiol, FSH, systolic and diastolic blood pressure parameters were not statistically significant between PCOS group and healthy control group. BMI, weight, height, waist-hip ratio, menstrual cycle, FGS, FPG, LH, Insulin, androstenedione, SHBG, total testosterone parameters were statistically significantly increased in the PCOS group compared to the healthy control group. The serum glutathione-S-transferase was significantly decreased insert ignore into journalissuearticles values( p < 0.05); in patients with PCOS, compared with control subjects. Prolidase insert ignore into journalissuearticles values(Pro); activity has been found to be significantly higher in women with PCOS than in the control group. Antioxidant enzyme GST activity has found to be decreased in PCOS patient group. Prolidase insert ignore into journalissuearticles values(Pro); enzyme is a candidate to be a leading parameter in the elucidation of the disease. In conclusion, the activities of glutathione-S-transferase and Prolidase insert ignore into journalissuearticles values(Pro); enzymes may be precursors in the etiopathogenesis of PCOS. This study has done in the literature for the first time. In addition, more work should be done in this area.
Keywords : PCOS, Prolidase, Glutathione s transferase GST,

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