BETAINE SUPPLEMENTATION PROTECTS RATS AGAINST ALCOHOL-INDUCED HEPATIC AND DUODENAL INJURY: AN HISTOPATHOLOGICAL STUDY

Authors : Ayşe ÇAKIR GÜNDOĞDU, Fatih KAR, Cansu ÖZBAYER

Pages : 220-233

Doi:10.59313/jsr-a.1232251

View : 33 | Download : 9

Publication Date : 2023-03-29

Article Type : Research Paper

Abstract :Betaine is a natural compound synthesized endogenously in animals, plants, and microorganisms and can be intaken by diet. There is a growing body of evidence that suggests betaine has properties that can protect against damage caused by oxidation, inflammation, and cell death in various human diseases. Additionally, recent studies suggest that betaine may help prevent and/or ameliorate tissue damage from alcohol consumption. In the present study, we evaluated histopathological changes in the liver and duodenum tissues stained with hematoxylin and eosin insert ignore into journalissuearticles values(H&E); in the four groups of twenty-eight Wistar albino rats: control group, betaine pre-treated group insert ignore into journalissuearticles values(250 mg/kg/bw, 21 days, i.g.);, acute ethanol ingested group insert ignore into journalissuearticles values(75% ethanol, 4 ml/kg/bw, i.g.); and betaine+ethanol group insert ignore into journalissuearticles values(75% ethanol, 4 ml/kg/bw, following betaine 250 mg/kg/bw, i.g.);. We found that betaine pre-treatment reduced significantly ethanol-induced hepatocyte degeneration, sinusoidal dilatation, hemorrhage, and inflammatory cell infiltration in the liver insert ignore into journalissuearticles values(p < 0.05);. We also showed that betaine protects duodenal mucosa significantly against epithelial damage at the tips of villi and hemorrhage insert ignore into journalissuearticles values(p < 0.001);. Collectively, this study indicated that betaine supplementation could protect against histopathological changes induced by ethanol in hepatic and duodenal tissues.
Keywords : Betaine, Ethanol, Liver, Duodenum, Histopathological changes

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