Epileptik Hastalarda Tedavi Öncesi Ve Sonrası Serum Çinko Ve Bakır Düzeyleri

Authors : C MARANGOZ, Mk ONAR, G TUNALI, C ÇELİK

Pages : 0-0

Doi:10.5835/jecm.v9i2.399

View : 27 | Download : 7

Publication Date : 2009-12-22

Article Type : Other Papers

Abstract :SERUM ZINE AND COPPER LEVELS OF EPILEPTIC PATIENTS BEFORE AND AFTER DRUG THERAPY ✓ In 42 epileptic patients the serum levels of copper insert ignore into journalissuearticles values(Cu); and zinc insert ignore into journalissuearticles values(zn); were determined before drug therapy had begun by atomic absorption spectrophotometry. In 16 of these patients the serum levels of Zn and Cu were also determined at least 3 months after therapy. The results were compared with each other and a control comprising 20 healthy individuals. The mean serum Zn levels of the patients prior to drug therapy, undergoing therapy and the control group were 79.42+17.7 , 83.6+18.3 and 86.95+ 18.61 Hg/100 ml respectively. The mean serum copper levels of the patients prior to therapy, undergoing therapy and the control group were 117+ 21.9, 123.1+18.4 and 119.4, respectively. There were no statistically significant differences bet¬ween the groups insert ignore into journalissuearticles values(p> 0.05);. Serum Zn levels decreased in patients using diphenylhydantoin insert ignore into journalissuearticles values(DDH); and increased in patients using carbamazepin insert ignore into journalissuearticles values(CBZ);. But, neither of these results were statistically significant. However, serum Cu levels increased significantly in patients using CBZ insert ignore into journalissuearticles values(p 0,05);. Difenilhidantoin insert ignore into journalissuearticles values(DPH); kullanan hastalarda serum Zn düzeyinde azalma, Cu düzeyinde ise artış saptandı. Fakat sonuçlar istatistiksel olarak anlamsızdı. Yalnız karbamazepin insert ignore into journalissuearticles values(CBZ); kullanan hastalarda serum Cu düzeyinde anlamlı artış görüldü insert ignore into journalissuearticles values(p<0.05);. Sonuç olarak epileptik hastaların serum Cu ve Zn düzeylerinde ilaç tedavisi öncesi kontrol gru¬buna göre önemli fark olmadığı, CBZ tedavisinden sonra hastaların serum Cu düzeylerinde görülen artışın karbamazepinin santral veya periferik etkilerine bağlı olabileceği düşünüldü.
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