Kalsiyum Kanal Blokeri Nifedipinin Monosinaptik Reflekslere Etkisi

Authors : O GENÇ, N TAŞÇI, Ş DEMİR, C MARANGOZ

Pages : 0-0

Doi:10.5835/jecm.v13i1.652

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Publication Date : 2009-12-23

Article Type : Other Papers

Abstract :The effects of calcium channel blocker, nifedipine on spinal monosynaptic reflexes were investigated in spinal cats. Nifedipine was administrated-locally insert ignore into journalissuearticles values(10, 50, 100s |imol/l); and intraperitoneally insert ignore into journalissuearticles values(5; 10, 20 mg/kg);. Adult cats insert ignore into journalissuearticles values(n=10);, weighing 1,5-3 kg were anesthetized with ketamine insert ignore into journalissuearticles values(50 mg/kg, I.M.); and artificially ventilated. Animals were spinalized at C j level. A laminectomy was perfor¬med in the lumbosacral region. The ventral and dorsal roots of segment L5 were isolated and a pouch of skin was formed at the site of the dissection, to allow the exposed tissues to be covered with liquid paraffin, which was kept at 38.5±0.5°C with a heating pad. A po-lyethylene cannula was introduced into the left carotiid artery to moniter blood pressure, which was kept above 100 mmHg. The dorsal root of segment L5 was placed on a silver-silver chloride wire electrode for sti-mulation throgh an isolatin unit. The reflex potentials were recorded from the ipsilateral L5 ventral root, mounted on a silver-silver chloride wire electrode. Both systemic and local application of nifedipine produced a dose-dependent decrease in the amplitude of the monosynaptic reflexes insert ignore into journalissuearticles values(p 0.05);. Bu sonuçlar bize omirilikte voltaja bağımlı kalsiyum kanallarının olabileceğini ve refleks cevabın düzenlenmesinde voltaja bağımlı kalsiyum kanallarının rol oynayabileceğini düşündürmektedir.
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