Çocukluk Çağı Ewing Sarkomlu Olguların Retrospektif Değerlendirilmesi

Authors : Beyhan BÜLBÜL, Murat ELLİ, Ayhan DAĞDEMİR, Nevzat DABAK, Sabri ACAR, Sancar BARIŞ, Mbekir SELÇUK, Gönül OĞUR

Pages : 66-72

Doi:10.5835/jecm.v27i2.1393

View : 40 | Download : 12

Publication Date : 2011-02-10

Article Type : Other Papers

Abstract :Bu çalışmada Çocuk Hematoloji-Onkoloji Bilim Dalı’nda takip ve tedavi edilen 27 Ewing Sarkomlu olgunun epidemiyolojik ve klinik özellikleri, tedavi sonuçları, uzun dönem komplikasyonları retrospektif olarak incelenmiştir. Olguların insert ignore into journalissuearticles values(n=27); ortalama tanı yaşı 11.36 ±3.98 yıl insert ignore into journalissuearticles values( 8 ay- 17.9); olup, erkek/kız oranı 1.7 olarak saptandı. En sık başvuru yakınmalarının lokalize ağrı insert ignore into journalissuearticles values(%96.3); ve şişlik insert ignore into journalissuearticles values(%100); olduğu görüldü. Primer tümör bölgesi 16 olguda insert ignore into journalissuearticles values(%59.3); uzun kemiklerde, 11 olguda insert ignore into journalissuearticles values(%40.7); aksiyel kemiklerde saptandı. Primer lezyonun yerleştiği kemikler sırasıyla femur insert ignore into journalissuearticles values(%26);, tibia insert ignore into journalissuearticles values(%14.8);, pelvis insert ignore into journalissuearticles values(%14.8); ve fibula insert ignore into journalissuearticles values(%11.1); idi. Başvuru anında 3 olguda insert ignore into journalissuearticles values( %11.1 ); kemik iliği tutulumu tespit edildi. Toplam 9 olguda insert ignore into journalissuearticles values(%33.3); tanı sırasında uzak yayılım saptandı. 23 olguya insert ignore into journalissuearticles values(%92); neoadjuvan kemoterapi, 17 olguya insert ignore into journalissuearticles values(%77.2); adjuvan kemoterapi uygulandığı tespit edildi. Olguların 13’üne ekstremite koruyucu cerrahi, 2’sine amputasyon yapıldığı saptandı. Radyoterapi olguların %65.3’ünde uygulandı insert ignore into journalissuearticles values(n=17); ve radyoterapi yeri 11 olguda primer tümör bölgesine, 5 olguda metastaz bölgesine, 1 olguda hem primer tümör hem metastaz bölgesine yönelik idi. Olgularının ortalama ve ortanca izlem süreleri sırasıyla 35.5 ve 19 ay insert ignore into journalissuearticles values(en fazla 355 ay); idi. Sağ kalım analizleri sonucunda toplam sağ kalım oranı %22.4±10.9 olarak saptandı. Retrospective assessment of patients with pediatric Ewing’s sarcoma In this study, 27 patients with Ewing’s sarcoma admitted to Pediatric Hematology and Oncology Department were evaluated retrospectively. The epidemiologic and clinical features, treatment results, long term side effects of therapy of 27 patients with Ewing’s sarcoma were analyzed. The mean age of patients with Ewing’s sarcoma insert ignore into journalissuearticles values(n=27); was 11.36 ±3.98 years insert ignore into journalissuearticles values(range,8 months-17.9 years); and male/female ratio was 1.7. The most common complaints were pain insert ignore into journalissuearticles values(96.3%); and swelling insert ignore into journalissuearticles values(100%);. A total of 16 insert ignore into journalissuearticles values(59.3%); primary tumors were located in an extremity, whereas 11 insert ignore into journalissuearticles values(40.7%); occured in the axial skeleton. The most common primary lesion sites were femur insert ignore into journalissuearticles values(26%);, tibia insert ignore into journalissuearticles values(14.8%);, pelvisinsert ignore into journalissuearticles values(14.8%); and fibula insert ignore into journalissuearticles values(11.1%); respectively. At diagnosis 3 patients insert ignore into journalissuearticles values(11.1%); had bone marrow metastases. A total of 9 patients insert ignore into journalissuearticles values(33.3%); had metastases at diagnosis. 23 patients insert ignore into journalissuearticles values(92%); received neoadjuvant chemotherapy and 17 patients received insert ignore into journalissuearticles values(77.2%); adjuvant chemotherapy. Limb salvage surgery was applied in 13 patients and amputation was made in 2 patients. Seventeen patients insert ignore into journalissuearticles values(65.3%); received radiotherapy; to the primary lesion site in 11 patients, the metastatic site in 5 patients, and both sites in one patient. The mean and median follow-up of patients with Ewing’s sarcoma was 35.5 and 19 months respectively insert ignore into journalissuearticles values(maximum 355 months);. The overall survival rate was 22.4±10.9 % .
Keywords : Anahtar Kelimeler Ewing sarkom, çocukluk çağı, retrospektif, analiz Key Words Ewings sarcoma, childhood, retrospective, analyze

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