Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism

Authors : Fatma UÇAR, Sümeyya AKYOL, Gulfer OZTURK, Zeynep GINIS, Gonul ERDEN, Mine TASPINAR, Abdullah ARZUHAL, Tuncay DELIBASI

Pages : 77-80

View : 50 | Download : 8

Publication Date : 2014-09-10

Article Type : Research Paper

Abstract :Increasing numbers of researches have indicated the relationship between serum vitamin D level and several autoimmune diseases, because it has important roles in immune regulation. However, the role of vitamin D in the etiopathogenesis of these diseases is not well understood. Similarly, the detailed mechanism of vitamin D action on thyroid hormone metabolism and autoimmune thyroid diseases is still poorly understood. It was recently reported that patients with autoimmune thyroid disease showed lower vitamin D levels. However, there are few studies dealing with vitamin D status in elderly patients with subclinical hypothyroidism. We therefore aimed to investigate vitamin D levels in elderly patients with subclinical hypothyroidism. In the present study, a total of 37 patients insert ignore into journalissuearticles values(>70 years old); with subclinical hypothyroidism and 40 healthy controls insert ignore into journalissuearticles values(>70 years old); were retrospectively analyzed. Serum levels of free triiodothyronine insert ignore into journalissuearticles values(fT3);, free thyroxine insert ignore into journalissuearticles values(fT4); and thyroid-stimulating hormone insert ignore into journalissuearticles values(TSH); were analyzed by chemiluminescence immunoassay insert ignore into journalissuearticles values(Centaur XP, Siemens Healthcare Diagnostics Inc., Tarrytown, USA);. Serum levels of 25-Hydroxy vitamin D insert ignore into journalissuearticles values(25-OH D); were measured by chemiluminescence immunoassay insert ignore into journalissuearticles values(DiaSorin, Liaison, Italy);. Serum anti thyroid peroxidase insert ignore into journalissuearticles values(anti-TPO); and anti thyroglobulin insert ignore into journalissuearticles values(anti-TG); were measured using a solid-phase, enzyme-labeled, chemiluminenescent sequential immunometric assay insert ignore into journalissuearticles values(Immulite 2000 XPi, Siemens Healthcare Diagnostics Inc., Tarrytown, USA);. There was no significant difference between groups in terms of age and gender distribution. Serum TSH, anti-TPO and anti- TG levels in elderly patients with subclinical hypothyroidism showed higher values than healthy controls as expected. Serum 25-OH D levels in elderly patients with subclinical hypothyroidism were lower than healthy controls insert ignore into journalissuearticles values(p<0.001);. These data may suggest association between serum 25-OH D levels and subclinical hypothyroidism in elderly patients. Further studies are needed to determine whether vitamin D insufficiency is a casual factor in the etiopathogenesis of subclinical hypothyroidism in elderly patients or rather a consequence of the disease.
Keywords : Autoantibodies, Elderly, Subclinical hypothyroidism, Vitamin D

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