Examining the relationship between vitamin D levels and Helicobacter pylori infection and its effect on the hypothalamic-pituitary-adrenal axis in dyspeptic patients

Authors : Huseyin KORKMAZ, Suleyman IPEKCI, Suleyman BALDANE, Mehmet SOZEN, Sedat ABUSOGLU, Levent KEBAPCILAR

Pages : 109-116

View : 42 | Download : 16

Publication Date : 2015-11-17

Article Type : Research Paper

Abstract :  The purpose of this study was to determine whether or not Helicobacter pylori insert ignore into journalissuearticles values(H. pylori); infection affects the hypothalamic-pituitary-adrenal insert ignore into journalissuearticles values(HPA); axis and to evaluate the association between vitamin D levels with H. pylori infected and eradicated patients. The glucagon stimulation test insert ignore into journalissuearticles values(GST); was used to assess the HPA gland axis. An H. pylor i infection was diagnosed based on the rapid urease test and histology. All infected patients received triple eradication therapy. Three months after the treatment, 14 C urea breath test was reinstituted, and GST was repeated in patients who were negative for H. pylori . Of the 43 patients, 20 insert ignore into journalissuearticles values(46%); were found to have a lower mean value of peak cortisol than normal responses to the GST in the H. pylori -infected subjects. In 29 subjects, H. pylori infection was successfully eradicated. Twelve insert ignore into journalissuearticles values(41%); out of 29 subjects were defined as having a blunted GST response and 17 insert ignore into journalissuearticles values(%59); subjects had normal HPA axis response to GST in the H. pylori -eradicated subjects. A significant correlation between low 25-hydroxyvitamin D 3 insert ignore into journalissuearticles values(25insert ignore into journalissuearticles values(OH);D 3 ); level and low peak cortisol response to GST was identified in the H. pylori -infected subjects. After H. pylori eradication, the positive correlation between 25insert ignore into journalissuearticles values(OH);D 3 level and high peak cortisol response to GST was also identified. Mean 25insert ignore into journalissuearticles values(OH);D 3 levels were lower in the H. pylori -infected subjects than in the H. pylori -eradicated subjects. Our results indicate an increased prevalence of blunted glucocorticoid response to GST in patients with infected H. pylori . Vitamin D deficiency is also common in the H. pylori -infected subjects and associated with blunted glucocorticoid response. These findings suggest that H. pylori eradication increases the cortisol response to GST. Vitamin D supports adrenal/cortisol production whereby a deficiency can result blunted glucocorticoid response to GST in patients with infected H. pylori . 
Keywords : Cortisol, Dyspeptic patients, Helicobacter pylori, Hypothalamic pituitary adrenal axis, Vitamin D

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