Lack of association between IRGM1 (rs13361189), PTGER4 (rs 1373692) and CARD8 (rs 2043211) polymorphism and Behçet’s disease: A study from Turkey

Authors : Sibel DOGAN, Basak YALCİN, Nilgun ATAKAN, Ahu YORULMAZ, Ferda ARTUZ

Pages : 83-87

View : 37 | Download : 6

Publication Date : 2017-09-08

Article Type : Research Paper

Abstract :Behçet’s disease insert ignore into journalissuearticles values(BD); is a severe in ammatory vasculitis which is very common among Turkish population. Recently, IRGM1 insert ignore into journalissuearticles values(rs13361189);, PTGER4 insert ignore into journalissuearticles values(rs1373692); and CARD8 insert ignore into journalissuearticles values(rs2043211); polymorphisms are shown to be associated with several in ammatory diseases. In this study, we investigated the association of IRGM1 insert ignore into journalissuearticles values(rs13361189);, PTGER4 insert ignore into journalissuearticles values(rs1373692); and CARD8 insert ignore into journalissuearticles values(rs2043211); polymorphisms with BD and their probable implications on clinical manifestations of BD in a Turkish patient cohort. 116 patients and 150 healthy controls genomic DNA were studied. Allele-speci c primers were used for genotyping. No signi cant difference was found between patient and controls according to genotypic distribution and allelic frequencies of IRGM1 insert ignore into journalissuearticles values(rs13361189);, PTGER4 insert ignore into journalissuearticles values(rs1373692); and CARD8 insert ignore into journalissuearticles values(rs2043211); insert ignore into journalissuearticles values(p>0.05);. No statistically signi cant difference was found in genotypic or allellic distribution of the same polymorphisms according to gender or clinical characteristics between patients and controls insert ignore into journalissuearticles values(p>0.05);. Our study is to our knowledge the rst report from Turkey regarding BD and IRGM1 insert ignore into journalissuearticles values(rs13361189);, PTGER4 insert ignore into journalissuearticles values(rs1373692); and CARD8 insert ignore into journalissuearticles values(rs2043211); polymorphisms. IRGM gene polymorphisms seems to cause predilection for autoimmunity in certain ethnic groups but not in Turkish BD patients. CARD8 gene polymorphisms and other in ammasome related genes may play a role in immune pathomechanisms in BD and separate studies including BD patients with similar clinical characteristics are required for investigating different SNPs as a probable disease susceptibility factor. 
Keywords : Behçets disease, CARD8, IRGM1, PTGER4, SNP

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