Association of gamma-glutamyl transpherase activity with electrocardiographic indicators in coronary artery disease patients

Authors : Murat MERİC, Metin ÇOKSEVİM, Sabri DEMİRCAN, Korhan SOYLU, Serkan YUKSEL

Pages : 235-240

View : 51 | Download : 15

Publication Date : 2019-10-10

Article Type : Research Paper

Abstract :0 0 1 14 85 OMU Medical Faculty 1 1 98 14.0 544x376 Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:`Table Normal`; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:``; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:`Times New Roman`;} 0 0 1 230 1315 OMU Medical Faculty 10 3 1542 14.0 544x376 Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:`Table Normal`; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:``; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:`Times New Roman`;} Gamma-glutamyl transpherase insert ignore into journalissuearticles values(GGT); plays an important role in atherogenesis through its activity in oxidative processes, which has been demonstrated in clinical studies . The connection between serum GGT activity and noninvasive arrhythmia indicators in patients with coronary artery disease insert ignore into journalissuearticles values(CAD); is investigated in the present study. We examined patients insert ignore into journalissuearticles values(n = 254, 174 males, mean age 62 ± 8); diagnosed with coronary artery disease on the basis of clinical and angiographic findings. All patient data were assessed, including serum GGT activity, biochemical measurements, and demographic and electrocardiographic features. A positive correlation was found between GGT levels and P-wave dispersion insert ignore into journalissuearticles values(r = 0.299, p < 0.0001);; however, there was a negative correlation between GGT and ejection fraction insert ignore into journalissuearticles values(r = 0.216, p < 0.001);. On the other hand, no correlation was found between GGT and the following: Sokolow-Lyon voltage, Cornell voltage, Cornell product, corrected QT, and QT dispersion insert ignore into journalissuearticles values(p values are 0.728, 0.892, 0.551, 0.069, and 0.146, respectively);. When the patients were grouped according to gender, a significant association of GGT with P-wave dispersion and ejection fraction was observed in both of the groups. Nonetheless, a significant correlation between GGT and QTc was only found in the female group. In this study, we found that increased GGT activity was correlated with P-wave dispersion. These results indicate that there might be an increased risk of arrhythmias especially the atrial fibrillation in this patient population.
Keywords : Gamma glutamyl transpherase, Atherosclerosis, P wave dispersion, Coronary Artery Disease, Arrhythmias

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