Importance of atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H)

Authors : Murat ALAN, Muhammet Ali ORUÇ, Yasemin ALAN, Hakkı AYTAÇ, Duygu AYAZ, Volkan KARATAŞLI, Muzaffer SANCI

Pages : 113-119

View : 74 | Download : 12

Publication Date : 2020-03-02

Article Type : Research Paper

Abstract :In this study, we evaluated the biopsy counterparts of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion insert ignore into journalissuearticles values(ASC-H); cases. This was a cross-sectional, retrospective study on ASC-H cases. The follow-up results of ASC-H cases diagnosed during routine primary screening between 2011 and 2018 were evaluated, and the relationship between clinicopathological parameters, high risk Human Papilloma Virus insert ignore into journalissuearticles values(hrHPV); test and patients’ ages at diagnosis were evaluated. Among one hundred sixty-nine ASC-H patients, high grade squamous intraepithelial lesion insert ignore into journalissuearticles values(HSIL); was detected in 56 insert ignore into journalissuearticles values(33.1%);, low grade squamous intraepithelial lesion insert ignore into journalissuearticles values(LSIL); in 59 insert ignore into journalissuearticles values(35%);, squamous cell carcinoma in 5 insert ignore into journalissuearticles values(3%); and adenocarcinoma in 1 insert ignore into journalissuearticles values(0.5%);. HPV 16 was detected in 41 insert ignore into journalissuearticles values(24.4%); cases and HPV 18 in 26 insert ignore into journalissuearticles values(16%); cases, and 51 patients had low risk of HPV insert ignore into journalissuearticles values(lrHPV);. The mean age of the patients with hrHPV was 31.78 ± 8.22, and the mean age of the patients with lrHPV was 34.77 ± 5.47. HPV positivity in ASC-H smears was significantly correlated with age insert ignore into journalissuearticles values(p = 0.004);. General linear regression analysis showed that biopsy results were significantly correlated with HPV in high-risk patients compared to low-risk patients. hrHPV evaluation in ASC-H follow-up is significant for cervical premalignant lesion. A management strategy that requires close monitoring in women with ASCH and under 40 years old, especially in association with hrHPV, should be considered.
Keywords : ASC H, Cervical Premalign Lesion, Histopathology, HPV

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