Association of anteroseptal hypokinesia after myocardial infarction with LDLR variation: A cross-sectional case-control study

Authors : Pegah POURZARGHAM, Mahboobeh AZADİ, Monireh ATAOLLAHİ, Hamed FOULADSERESHT, Shahdad KHOSROPANAH, Mehrnoosh DOROUDCHİ
Pages : 87-95
View : 41 | Download : 13
Publication Date : 2020-04-30
Article Type : Research Paper
Abstract :Cholesterol-rich LDL insert ignore into journalissuearticles values(LDL-C); is a major atherogenic lipoprotein. Elevated content of LDL-C in serum is associated with the higher risk of atherosclerosis. The plasma LDL-C level is regulated by LDL receptor. The T allele of rs2228671 in LDLR may be associated with decreased LDL-C levels. We investigated the association of rs2228671 of LDLR with myocardial infarction insert ignore into journalissuearticles values(MI); in people from Fars province of Iran. In this study 248 cases with MI and 256 healthy blood donors were tested for their rs2228671 LDLR polymorphism by PCR-RFLP method. The CC genotype of the rs2228671 single nucleotide polymorphism tended to be more common in patients while TT showed a higher frequency in the control group. Patients with anteroseptal hypokinesia had a significantly higher frequency of the CC genotype compared with other patients insert ignore into journalissuearticles values(p= 0.04, OR 8.217 and 95% CI 0.4755 to 142);. Also frequency of C allele was increased as compared with that of the T allele in patients with anetroseptal hypokinesia insert ignore into journalissuearticles values(p=0.05, OR 7.637 and 95% CI 0.4367 to 124.6);. There was also a significant increase of CT genotype in patients with abnormal heart rate insert ignore into journalissuearticles values(p=0.014);. A significantly higher frequency of the CC genotype in patients with anetroseptal hypokinesia and its decrease in patients with abnormal heart rate suggest a complex relationship between LDLR variants and complications of MI.
Keywords : Low density lipoprotein receptor, polymorphism, single nucleotide, myocardial Infarction, hypokinesia

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