Association of angiotensin-converting enzyme and nitric oxide synthase genes polymorphisms with the risk of myocardial infarction in Bangladesh

Authors : Md Bayejid HOSEN, Md Mehedi HASAN, Delowar HOSSAİN, Md Mostafijur RAHMAN, Jyosna KHANAM, Aklima AKTER, Yearul KABİR, M Zakir Hossain HOWLADER

Pages : 127-134

View : 31 | Download : 11

Publication Date : 2020-09-11

Article Type : Research Paper

Abstract :Myocardial infarction is one of the leading manifestations of illness and death worldwide. The aim of the study was to find out the associations of ACE insert ignore into journalissuearticles values(I/D); and NOS3 insert ignore into journalissuearticles values(G894T & 4b/a); genes polymorphisms with the occurrence of myocardial infarction insert ignore into journalissuearticles values(MI); in Bangladeshi population. The study was conducted on 100 cardiac patients experiencing MI and 150 healthy volunteers with no complications. The genotyping was done using PCR and PCR-RFLP methods and the biochemical parameters were measured using auto biochemistry analyzer. Over all, the serum Troponin I, AST and ALP levels were significantly insert ignore into journalissuearticles values(p<0.01, and 0.001, respectively); higher and the albumin level was significantly insert ignore into journalissuearticles values(p<0.001); lower among the patients. The percentage of DD genotypes of ACE gene was significantly insert ignore into journalissuearticles values(p <0.05); higher in patients. The individual with DD allele was at 3.28-fold increased risk insert ignore into journalissuearticles values(OR = 3.28; 95 % CI = 1.6 to 6.7; p < 0.01); of experiencing MI while individual with ID genotype was at lower risk. In addition, the cigarette smokers with DD genotypes were found to have a 4.1-fold increased risk to develop cardiac disease insert ignore into journalissuearticles values(OR= 4.1; 95 % CI=1.5 to 11.2; p < 0.01);. The frequencies of NOS3 insert ignore into journalissuearticles values(G894T & 4a/b); genotypes in the patients and controls were almost similar. There were no significant differences among the biochemical parameters for different genotypes. Thus our recent study suggested that the ACE insert ignore into journalissuearticles values(I/D); gene may have strong associations with the occurrence of MI and DD genotype would be considered as a risk factor.
Keywords : ACE insertion deletion, Bangladesh, Myocardial infarction, PCR RFLP, Polymorphism

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