Successful treatment with intravenous lipid emulsion of severe tricyclic antidepressant intoxication

Authors : Hızır AKDEMİR, Yavuz CENİK, Mustafa URAS, Neslihan ÜNAL

Pages : 43-46

View : 40 | Download : 11

Publication Date : 2021-01-26

Article Type : Other Papers

Abstract :An overdose of amitriptyline has neurological and cardiovascular side effects insert ignore into journalissuearticles values(psychosis, lethargy, coma, hypotension, and dysrhythmia);. A 19-year-old female patient was admitted to our emergency service after a suicide attempt by amitriptyline ingestion of unknown amount. Her follow-up demonstrated deteriorating consciousness and vital signs, she had a generalized tonic-clonic seizure, and her electrocardiogram insert ignore into journalissuearticles values(ECG); revealed QRS interval widening followed by a ventricular tachycardia insert ignore into journalissuearticles values(VT); attack. The patient was treated with intravenous insert ignore into journalissuearticles values(IV); diazepam insert ignore into journalissuearticles values(Diazem®); to control the epileptic seizure, IV lidocaine insert ignore into journalissuearticles values(Aritmal®); to stop the VT attack, and IV sodium bicarbonate due to QRS interval widening. The patient was given norepinephrine bitartrate insert ignore into journalissuearticles values(Steradine®); and dopamine hydrochloride insert ignore into journalissuearticles values(Dopamine®); due to low blood pressure. Intravenous lipid emulsion insert ignore into journalissuearticles values(ILE); therapy was started due to the uncontrolled rhythm and hypotension. Here, we present a case report of a comatose patient with dysrhythmia due to amitriptyline overdose who responds to ILE therapy.
Keywords : Tricyclic antidepressant, Intoxication, Dysrhythmia, Coma, Lipid emulsion, Treatment

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