The role of triglyceride glucose index in predicting in-hospital adverse cardiovascular outcomes in patients with acute coronary syndrome

Authors : Sara ÇETİN ŞANLIALP, Gokay NAR

Pages : 583-588

View : 33 | Download : 9

Publication Date : 2021-10-09

Article Type : Research Paper

Abstract :Previous studies have shown the association of triglyceride glucose insert ignore into journalissuearticles values(TyG); index with metabolic syndrome insert ignore into journalissuearticles values(MetS);, cardiovascular diseases insert ignore into journalissuearticles values(CAD); and long-term adverse cardiovascular outcomes. However, to best our knowledge, the relation between TyG index and in-hospital adverse cardiovascular outcomes in acute coronary syndrome insert ignore into journalissuearticles values(ACS); has not been reported yet. Hence, in this study, we aimed to evaluate the role of the TyG index in predicting in-hospital adverse cardiovascular outcomes in ACS and to compare its performance with the Global Acute Coronary Events Register insert ignore into journalissuearticles values(GRACE); risk score. 170 patients diagnosed with ACS and underwent coronary angiography were retrospectively analyzed. The TyG index was calculated using the following formula: ln [fasting triglycerides insert ignore into journalissuearticles values(mg/dL);×fasting blood glucose insert ignore into journalissuearticles values(mg/dL);/2]. Receiver operating characteristics insert ignore into journalissuearticles values(ROC); curve analysis was used to evaluate the performance of the TyG index and GRACE risk score in predicting in-hospital adverse cardiovascular outcomes. A binary logistic regression model was applied to determine the independent predictors of in-hospital adverse cardiovascular outcomes. In the initial analysis, the patients with adverse cardiovascular outcomes had high TyG index and GRACE risk scores insert ignore into journalissuearticles values(p=0.011, p<0.001);. In ROC analysis, the GRACE score performed better in predicting in-hospital adverse cardiovascular outcomes compared to TyG index insert ignore into journalissuearticles values(AUC:0.716, p<0.001; AUC:0.588, p=0.054 repectively);. In binary logistic regresyon analysis, left ventricular ejection fraction insert ignore into journalissuearticles values(LVEF);, multi-vessel disease and GRACE risk score were independent predictors for in-hospital adverse cardiovascular outcomes insert ignore into journalissuearticles values(OR: 0.840, 95% CI: 0.791-0.891, p<0.001; OR: 3.581, 95% CI:1.382-9.282, p=0.009; OR= 1.017, 95% CI: 1.001-1.034, p=0.04 respectively);. The study findings releaved that TyG index was scant in predicting in-hospital adverse cardiovascular outcomes compared to GRACE risk score. The independent predictors for in-hospital adverse cardiovascular outcomes were LVEF, multivessel disease and GRACE risk score.
Keywords : acute coronary syndrome, cardiovascular outcomes, GRACE, triglyceride glucose index

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