Relationship between index of cardio-electrophysiological balance and hydroxychloroquine in patients with COVID-19

Authors : Şebnem NERGİZ ÖZTÜRK, Önder ÖZTÜRK
Pages : 472-476
View : 109 | Download : 7
Publication Date : 2022-03-18
Article Type : Research Paper
Abstract :Background: Hydroxychloroquine insert ignore into journalissuearticles values(HCQ); treatment is frequently prescribed for coronavirus disease 2019 insert ignore into journalissuearticles values(COVID-19);. Electrocardiographic insert ignore into journalissuearticles values(ECG); monitorization is recommended because HCQ causes QT interval prolongation. The index of cardioelectrophysiological balance insert ignore into journalissuearticles values(iCEB);, calculated as the ratio of QT interval / QRS duration. In recent years, iCEB has been described as an important marker for dysrhthmias. Decreased or increased iCEB is related with lethal ventricular arrhythmias. Aim of the study: In our research, we purposed to investigate the relationship between iCEB and HCQ in patients with COVID-19. Methods: 200 patients insert ignore into journalissuearticles values(males, 84 ; females, 116 ; 60.4 ± 13.8 years); with PCR positive and chest tomography findings compatible with COVID-19 pneumonia were registered in the research. Demographic, clinical, and laboratory data for all patients were collected. ECG was recorded from all patients on admission to COVID-19 clinic, in oral treatment with HCQ insert ignore into journalissuearticles values(200 mg, twice daily); for at least 5 days. iCEB insert ignore into journalissuearticles values(QT/QRS); was calculated from the 12-lead electrocardiogram. Results: The mean age of the patients was 60.4 ± 13.8 years. Compared to admission ECG, ECG on day 5 showed significant increases in heart rate, QT interval, corrected QT insert ignore into journalissuearticles values(QTc); interval, and iCEB. Conclusions: Our results suggested that iCEB is related with HCQ treatment in patients with COVID-19. Previous studies have show that high iCEB is related with torsade de Pointes insert ignore into journalissuearticles values(TdP);, ventricular tachycardia.
Keywords : ECG, Electrodiagnosis, Hydroxychloroquine, arrhythmia, COVID 19

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