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  • Journal of Experimental and Clinical Medicine
  • Volume:40 Issue:1
  • SCUBE-1 as a novel predictor of thromboembolic event

SCUBE-1 as a novel predictor of thromboembolic event

Authors : Hatice Şeyma AKÇA
Pages : 197-198
View : 96 | Download : 165
Publication Date : 2023-03-18
Article Type : Other Papers
Abstract :SCUBE-1 is a newly identified, secreted cell surface protein that is determined during early embryogenesis. This protein consists of cascading EGF-like repeats following the N-terminal signal peptide sequence, a spacer region, cysteine-rich repeat motifs, and a CUB domain at the C-terminus. These molecules are stored in alpha granules in inactivated platelets, translocated to the platelet surface after activation by thrombin, secreted as small soluble fragments, and incorporated into the thrombus.
Keywords : SCUBE 1, thromboembolic events, myocardial infarction

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