Hypoglossal nerve stimulation in the treatment of obstructive sleep apnea in down syndrome patients: A systematic review and meta-analysis

Authors : Yasmeen Jamal Alabdallat, Hamza Khaled Alsalhi, Benyameen Yacoub Mosa, Yousef Hawas, Toka Elboraay, Ibraheem M Alkhawaldeh, Jaber H Jaradat, Obada Ahmad Abunar, Adam M Abdallah, Zaid Kamal

Pages : 407-416

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Publication Date : 2024-05-19

Article Type : Review Paper

Abstract :Obstructive sleep apnea (OSA) is highly prevalent in individuals with Down syndrome (DS), affecting more than 50% of this population during childhood and reaching up to 100% in adulthood. This disorder poses significant clinical consequences, including impaired cognitive function, developmental delay, and cardiovascular complications. To address this, direct hypoglossal nerve stimulation (HNS) has been approved as a treatment modality for OSA. Recent studies have shown a significant positive correlation between HNS voltage and post-apnea-hypopnea index (AHI) levels in DS and non-DS patients. However, concerns regarding the reliability of some findings have been raised, emphasizing the need for further research to underline the usefulness of HNS in treating OSA in DS patients. This meta-analysis provides a comprehensive review and analysis of the available case reports, case series, and cohort studies to evaluate the safety and efficacy of HNS in treating OSA in Down syndrome patients.
Keywords : OSA, Down Syndrome, Apnea, Hypoglossal Nerve, stimulation

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