The effect of lymphoid antigen expression on prognosis of the patients with acute myeloblastic leukemia

Authors : Ö ALPDOĞAN, D DEMİRALP, T AKOĞLU, M BAYIK

Pages : 28-32

View : 28 | Download : 5

Publication Date : 1997-01-01

Article Type : Research Paper

Abstract :Objective: Lymphoid antigen expression is very common in patients with acute myeloblastic leukemia insert ignore into journalissuearticles values(AML);, but the predictive value of lymphoid antigen expression on the prognosis of AML remains unclear. In this study we tried to find out the effect of lymphoid antigen expression on prognosis of the patients with acute myeloblastic leukemia. Methods: Seventy patients with AML, admitted to Marmara University Hospital between January 1989 and December 1995, were analyzed for blast cell lymphoid antigen expression, and prognosis. Lymphoid antigens examined on the myeloblasts were CD2, CD3, CD7, CD10 and CD19. Results: Twenty-four patients insert ignore into journalissuearticles values(34.2%); had one or more positive lymphoid antigens present in their blasts. Six patients had T lymphoid associated antigen insert ignore into journalissuearticles values(8.5%);, 12 patients had B lymphoid associated antigen insert ignore into journalissuearticles values(17.1%); and six patients had both B and T lymphoid antigens insert ignore into journalissuearticles values(8.5%);. No differences were found between lymphoid marker positive and negative groups in terms of age, leukocyte count on admission, serum LDH levels, complete remission rate, relapse rate and survival. Four out of six patients insert ignore into journalissuearticles values(67%); expressing both T and B lymphoid antigens died within the first month of the diagnosis. The early mortality rate of this group was different from the patients whose blasts expressed T or B lymphoid antigens alone insert ignore into journalissuearticles values(67% v 11% p<0.02);, and was higher than that was seen in the lymphoid antigen negative group although not statistically different insert ignore into journalissuearticles values(67% v 32% p:0.1);. Conclusion: Although the number of patients was limited, T and B lymphoid antigen coexpression on AML blasts may be a predictor of poor outcome and this needs to be further investigated in a large scale of clinical trial.
Keywords : Acute myeloblastic leukemia, lymphoid associated antigens, T lymphocyte associated antigens, B lymphocyte associated antigens

ORIGINAL ARTICLE URL