The effects of melatonin on the striatum

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Marmara Medical Journal
Volume:34 Issue:3
The effects of melatonin on the striatum

The effects of melatonin on the striatum

Authors : Sinem GERGIN, Ozlem KIRAZLI, Hatice BORACI, Sercan Dogukan YILDIZ, Umit Suleyman SEHIRLI

Pages : 234-340

Doi:10.5472/marumj.1012077

View : 26 | Download : 8

Publication Date : 2021-10-27

Article Type : Research Paper

Abstract :Objective: Some of the neurological diseases cause morphologic changes in the striatal neurons. Medial forebrain bundle insert ignore into journalissuearticles values(MFB); lesion is a commonly used method to produce a Parkinsonian model rat. Melatonin is a hormone which exerts a neuroprotective effect on the neurons. The aim of this study is to investigate the effect of melatonin on the dendritic morphology of striatal medium spiny neurons insert ignore into journalissuearticles values(MSNs); in rats with MFB lesion. Materials and Methods: Twelve male Wistar albino rats were given saline injections into the MFB and divided into sedentary and treatment groups. The treatment group was administered a 10 mg/kg dose of melatonin intraperitoneally for 30 days. The lesion was confirmed histologically by Nissl staining. Golgi staining technique was applied to observe neuronal morphology. Neuronal structures were analysed from three-dimensional images by Neurolucida insert ignore into journalissuearticles values(MBF Bioscience); software. Results: The MFB lesion caused a reduction in the total dendritic length and in the number of dendritic endings. The melatonin enhanced the number of dendritic endings compared to the sedentary group. The melatonin led to an increase in the total spine density, spine densities of thin and mushroom types. Conclusion: Melatonin improved the dendritic degeneration due to MFB lesion.
Keywords : Dendritic spine, Melatonin, Golgi, Neurolucida

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