Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Authors : Ahmed Ramiz BAYKAN, Cemile BİÇER, Emre GERÇEKER, Özcan EREL, Serkan CERRAH, Bülent ALBAYRAK, Mustafa UTLU, Ayşe KARGILI

Pages : 948-956

Doi:10.18621/eurj.443557

View : 35 | Download : 10

Publication Date : 2019-11-04

Article Type : Research Paper

Abstract :Objectives: The aim of the study was to evaluate the oxidative stress level in patients, diagnosed with Helicobacter pylori infection, using a novel marker insert ignore into journalissuearticles values(thiol/ disulphide homeostasis); and to compare the level in infected individuals with that in healthy volunteers. Methods: A total of 60 patients diagnosed with gastritis, erosive gastritis or ulcer by endoscopy were included and biopsied. The 30 patients diagnosed with H. pylori and 30 healthy individuals were enrolled. Medical histories, physical examination results, body mass index insert ignore into journalissuearticles values(BMI);, hemogram, free triiodothyronine insert ignore into journalissuearticles values(FT3);, free thyroxine insert ignore into journalissuearticles values(FT4);, thyroid stimulating hormone insert ignore into journalissuearticles values(TSH);, urea, creatinin, aspartate aminotransferase insert ignore into journalissuearticles values(AST);, alanine aminotransferase insert ignore into journalissuearticles values(ALT);, albumin, total cholesterol, triglycerides , high density lipoprotein insert ignore into journalissuearticles values(HDL);, low density lipoprotein); LDL and  thiol/disulphide levels obtained in the study groups were compared. Results: There was no significant difference between the total thiol , native  thiol , di sulphide /native  thiol a nd dis sulphide /total  thiol  ratios of the patient and control group. When the H . pylori patients were stratified by endoscopic evaluation as having mild insert ignore into journalissuearticles values(superficial gastritis or normal appearance); or severe insert ignore into journalissuearticles values(ulcer or erosive areas); symptoms, there were significant differences in disulphide, disulphide /native thiol, disulphide/ total thiol and native thiol / total thiol levels . We also observed BMI and the total, native thiol levels of H. pylori patients were inversely related.insert ignore into journalissuearticles values( r: 0.562, p = 0.001; r: 0.0552, p = 0.002);. Conclusions: Thiol/disulphide homeostasis is likely to differ with both duration and severity of H. pylori infection. Further investigations are needed to investigate the effect of H. pylori on oxidative stress.
Keywords : Helicobacter pylori, thiol, oxidative stress

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