Clinical significance of mean platelet volume/lymphocyte ratio and mean platelet volume/platelet ratio in the exacerbation of chronic obstructive pulmonary disease

Authors : Emine ÖZSARI, Mehmet Zahid KOÇAK

Pages : 1001-1006

Doi:10.18621/eurj.443660

View : 53 | Download : 13

Publication Date : 2019-11-04

Article Type : Research Paper

Abstract :Objectives: Studies showing the role of systemic inflammation in c hronic obstructive pulmonary disease insert ignore into journalissuearticles values(COPD); are increasing. Particularly, importance of mean platelet volume insert ignore into journalissuearticles values(MPV); and neutrophil/lymphocyte ratio insert ignore into journalissuearticles values(NLR); for acute exacerbation of COPD has been reported. The use of MPV/lymphocyte ratio insert ignore into journalissuearticles values(MLR); and MPV/platelet ratioinsert ignore into journalissuearticles values(MPR); in acute exacerbation of COPD patients was investigated in our study, considering that MPV alone may be a more valuable marker of inflammation. Methods: Between March 2017 and March 2018, COPD patients who applied to Abant Izzet Baysal University School of Medicine, Chest Diseases outpatient clinic were examined. Results were retrospectively scanned from patient files after institutional approval. Sixty-four insert ignore into journalissuearticles values(60.4%); stable COPD and 42 insert ignore into journalissuearticles values(39.6%); acute exacerbation COPD patients were included in the study. Results: Seventy-one insert ignore into journalissuearticles values(67%); of patients were male and 35 insert ignore into journalissuearticles values(33%); were female. NLR was 2.26 insert ignore into journalissuearticles values(0.93-6.48); in stable patients and 4 insert ignore into journalissuearticles values(1.18-36); in acute attack patients insert ignore into journalissuearticles values( p < 0.001);; PLR was 137.44 insert ignore into journalissuearticles values(66.9-436.6); in patients with stable disease and 162.8 insert ignore into journalissuearticles values(85-1056.6); in patients with attack insert ignore into journalissuearticles values( p = 0.068);. MLR was 5 insert ignore into journalissuearticles values(2.92-25); in acute attack patients and 4 insert ignore into journalissuearticles values(1.89-8.67); in stable patients; this difference was statistically significant insert ignore into journalissuearticles values( p = 0.003);. MPV was found to be 7 insert ignore into journalissuearticles values(5.5-9.1); fL in patients with stable disease and 8 insert ignore into journalissuearticles values(5-13.4); fL in acute patients. This difference was statistically significant insert ignore into journalissuearticles values( p < 0.001);. MPR was found to be statistically significantly higher in acute patients than in patients with stable disease insert ignore into journalissuearticles values( p = 0.04);. WBC, neutrophil and CRP were found to be statistically significantly higher in acute patients than in stable patients insert ignore into journalissuearticles values( p < 0.05);. There was a statistically significant correlation between WBC and NLR insert ignore into journalissuearticles values(r = 0.269, p = 0.005); and between CRP and NLR insert ignore into journalissuearticles values(r = 0.379, p < 0.001);. Conclusions: Hemogram parameters from routine laboratory tests in COPD patients are cheap and easily accessible. It is important to detect the presence of subclinical inflammation in the stable phase, as well as to identify patients at risk of exacerbation. Prospective studies are needed to demonstrate correlations with inflammatory markers. 
Keywords : Mean platelet volume, neutrophil lymphocyte ratio, lymphocyte, platelet, chronic obstructive pulmonary disease

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