Toxoplasmosis in pregnancy: test, treatment and outcome

Authors : Ayşe KAYA KALEM, İmran HASANOĞLU, Müge AYHAN, Bircan KAYAASLAN, Fatma ESER, Yüksel OĞUZ, Filiz AVŞAR, Rahmet GÜNER

Pages : 296-303

Doi:10.18621/eurj.1039212

View : 39 | Download : 9

Publication Date : 2022-03-04

Article Type : Research Paper

Abstract :Objectives: The aim of this study was to share the results, follow-up, and treatment characteristics of our pregnant women who were followed-up with anti- Toxoplasma gondii Immunoglobulin insert ignore into journalissuearticles values(Ig); M positivity during pregnancy. Methods: Anti- T. gondii  IgM- and IgG-positive pregnant women were evaluated between 2014-2018. Demographic characteristics, treatment, and information about pregnancy were obtained from the electronic database. Pregnant women were divided into three groups; primary infection, no infection, and suspected infection in pregnancy. Primary and suspected infection in pregnancy were followed up congenital toxoplasmosis risky pregnancy. Fetal ultrasonography insert ignore into journalissuearticles values(USG);, T. gondii DNA polymerase chain reaction insert ignore into journalissuearticles values(PCR); result in amniotic fluid were recorded. Results: Twenty-four pregnant women with a mean age of 27.9 years were followed up. IgG avidity results were low in 37.5% insert ignore into journalissuearticles values(n = 9);, intermediate avidity in 8.3% insert ignore into journalissuearticles values(n = 2);, and high avidity in 54.2% insert ignore into journalissuearticles values(n = 13); of pregnant women. Eleven insert ignore into journalissuearticles values(45.9%); pregnant women had congenital toxoplasmosis risky pregnancy. Fetal USG was performed on ten pregnant women, and no signs of congenital toxoplasmosis were found. Amniocentesis was performed in 72.7% insert ignore into journalissuearticles values(n = 8); of the participants, and the amniotic fluid T. gondii DNA-PCR result was negative in all of them. Ten insert ignore into journalissuearticles values(90.9%); pregnancies resulted in mature birth and one insert ignore into journalissuearticles values(9.1%); resulted in miscarriage. Conclusions: Anti- T. gondii IgM positivity is an indication of acute infection. But IgM can persist for years, and be false-positive in pregnancy. Therefore, additional tests are required, and leading to emotional distress and unnecessary interventions in pregnacy women. These results can aid in developing an approach to screening and diagnosis of T. gondii infection in pregnancy.
Keywords : Toxoplasmosis, pregnancy, avidity, congenital toxoplasmosis, T gondii DNA polymerase chain reaction PCR, fetal ultrasonography

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