The effect of nasal steroids on retinal nerve fiber layer in patients with a family history of glaucoma

Authors : Mehmet Tahir ESKİ, İlhan ÜNLÜ

Pages : 222-230

Doi:10.18621/eurj.1111514

View : 91 | Download : 8

Publication Date : 2023-03-04

Article Type : Research Paper

Abstract :Objectives: We aimed at analyzing the effect of nasal steroids on intraocular pressure insert ignore into journalissuearticles values(IOP); and retinal nerve fiber layer thickness insert ignore into journalissuearticles values(RNFL); in patients with a family history of glaucoma who also use fluticasone propionate insert ignore into journalissuearticles values(FP group); and mometasone furoate insert ignore into journalissuearticles values(MF group);. Methods: Patients with a family history of glaucoma and suitable for using nasal steroids were included in the study population. IOP, anterior chamber depth insert ignore into journalissuearticles values(ACD);, axial length insert ignore into journalissuearticles values(AL); and central corneal thickness insert ignore into journalissuearticles values(CCT); and RNFL thickness measurements of the patients were carried out. Measurements were done on 3 levels, namely, one before starting the medication, the other 1 month after starting the medication and the last one 3 months after the medication. 3 groups were established in our study: patients who are using MF group and FP group and also C group insert ignore into journalissuearticles values(control group; healthy individuals who have a family history of glaucoma but not using any medication);. Results: The average age of patients in our study who were under medication was 33.2 ± 8.9 years. The study consisted of a total of 46 patients, 32 of whom were using nasal steroids and 14 belonging to the C group. It was found that global value in MF group decreased from 100.9 ± 7.7 to 99.6 ± 7.6 in the 3 rd month and ACD in MF group decreased from 3.2 ± 0.4 mm to 2.9 ± 0.4 mm in the 1 st month, both to be found statistically significant insert ignore into journalissuearticles values( p = 0.037 and p = 0.001 respectively);. During the RNFL thickness measurements of patients, it was found that Temporal insert ignore into journalissuearticles values(T); segment in FP group decreased from 82.1 ± 13.8 to 81.7 ± 13.3 in the first month and T segment in MF group decreased from 72.8 ± 12.0 to 71.3 ± 10.2 in 3 months, both decreases to be found statistically significant insert ignore into journalissuearticles values( p = 0.047 and p=0.003 respectively);. It was found that IOP in FP group increased from 15.3 ± 3.6 mm Hg to 17.7 ± 4.1 mm Hg in the 3 rd month hence found to be statistically significant insert ignore into journalissuearticles values( p = 0.006);. CCT in FP patients was found to be significantly higher in the 3 rd month insert ignore into journalissuearticles values( p = 0.025);. Conclusions: As a result of our study, it was found that nasal steroid usage in patients with a family history of glaucoma may cause an increase in IOP and thinning of the RNFL.
Keywords : Mometasone furoate, fluticasone propionate, intraocular pressure, retinal nerve fiber layer thickness

ORIGINAL ARTICLE URL