Pre-conception folic acid intake and attention deficit and hyperactivity disorder in children

Authors : Mehmet Erdem UZUN, Nazan KAYMAZ, Hakan AYLANC, Emel Sarı GÖKTEN, Hande ŞİRİN, Fatih BATTAL

Pages : 322-327

Doi:10.18621/eurj.1129774

View : 68 | Download : 9

Publication Date : 2023-03-04

Article Type : Research Paper

Abstract :Objectives: Attention Deficit Hyperactivity Disorder insert ignore into journalissuearticles values(ADHD); is a common disorder in children. It is thought to occur due to the interaction of many genetic and environmental factors during early  development. Many studies have been conducted to investigate the etiology of ADHD. Some have investigated neurobiology, and others have investigated malnutrition and trace element deficiency. To investigate the effect of folic acid intake during the pre-conception period in terms of ADHD development.  Methods: Five hundred and ninety-eight participants, 246 children with ADHD, and 352 healthy controls were enrolled. A questionnaire was completed, including socio-demographic information and the use of folic acid and other supplements such as a multivitamin, iron, and omega 3 during pregnancy. Data were examined to determine associations with ADHD. Mann-Whitney U tests for continuous variables, Pearson’s chi-square, and Fisher’s exact tests for categorical variables were used to compare groups.  Results: The use of folic acid during pre-pregnancy among mothers who had a child with ADHD was 13% and this was 31% in the control group insert ignore into journalissuearticles values( p < 0.001);. There was no statistically significant difference between the groups’ use of folic acid in pregnancy insert ignore into journalissuearticles values( p = 0.617);. Other situations related to ADHD were advanced maternal age insert ignore into journalissuearticles values( p < 0.001 for both groups);, abnormal double screening test results in pregnancy insert ignore into journalissuearticles values(27% vs. 5%, p < 0.001); and omega 3 use in pregnancy insert ignore into journalissuearticles values( p < 0.001);.  Conclusions: The use of folic acid before and during pregnancy is important for neurological development. However, there is little data on use before pregnancy in the literature. This study shows that folic acid taken before pregnancy may prevent ADHD in childhood. The present study recommends folic acid usage in planned pregnancy to prevent ADHD in the child. 
Keywords : Pre pregnancy, folic acid, attention deficit hyperactivity disorder, children

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