The relationship of bone marrow fibrosis at diagnosis with prognosis and survival in childhood acute lymphoblastic leukemia

Authors : Çiğdem ÖZDEMİR, Yeter DÜZENLİ KAR, Nilgün EROĞLU, Hilal SUSAM ŞEN, Yiğit ŞENOL, İbrahim EKER

Pages : 375-383

Doi:10.18621/eurj.1244314

View : 36 | Download : 9

Publication Date : 2023-03-04

Article Type : Research Paper

Abstract :Objectives: Our aim in this study is to investigate the effect of fibrosis at diagnosis on treatment and survival in childhood acute lymphoblastic leukemia insert ignore into journalissuearticles values(ALL);. Methods: This study is retrospective. We evaluated the relationship between patients\` age, white blood cell count at diagnosis, morphological blast percentage and flow cytometric blast percentage at diagnosis, day 15 th and day 33 th , absolute blast count in peripheral smear on day 8 th , and the degree of fibrosis in bone marrow biopsy at diagnosis in 36 pediatric patients. The fibrosis degree in biopsy on the thirty-third day after induction therapy was measured. Results: Twenty-eight insert ignore into journalissuearticles values(77.8%); cases were diagnosed B-ALL and 8 T-ALL insert ignore into journalissuearticles values(22.2%);. There was no statistically significant difference between the groups with and without fibrosis in terms of any parameter measured at the time of diagnosis, 8 th day, 15 th day, and 33 th day. No significant difference was found between the groups according to overall survival insert ignore into journalissuearticles values(OS);: the mean OS was 50.22 ± 5.44 months in the fibrosis group and 49.70 ± 3.96 months in the non-fibrosis group insert ignore into journalissuearticles values( p = 0.557);. Conclusions: There is a high detection rate of bone marrow fibrosis in ALL pediatric cases at the time of diagnosis. Nevertheless, fibrosis does not affect survival.
Keywords : Leukemia, fibrosis, bone marrow, childhood, lymphoblastic, microenvironment

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