Evaluation of Systemic Inflammation Associated with Celiac Disease

Authors : Şeyma Taştemur, Duygu Felek

Pages : 449-455

Doi:10.18663/tjcl.1701414

View : 87 | Download : 155

Publication Date : 2026-01-01

Article Type : Research Paper

Abstract :Aim: The ultimate goal of the study is to measure systemic inflammation in celiac disease and identify associated parameters, thus preventing systemic side effects by combating systemic inflammation in Celiac Disease (CD). Material and Methods: The Systemic Inflammatory Index (SII) was calculated as “platelet count × neutrophil count/lymphocyte count” in patients with CD and healthy individuals without a diagnosis of CD who were evaluated for other reasons, who applied to the Internal Medicine Clinics of our centers between 2015-2025. Demographic characteristics, Anti-tissue transglutaminase (Anti-TTG), anti-gliadin, Human leucocyte antigenes HLADQB102, HLADQA103, HLADQA105, hemogram, ESR, CRP, and routine biochemical markers were extracted from medical records. Results: A total of 200 participants were included: 102 CD patients and 98 controls. Females constituted 60.1% of the cohort. The mean SII was 636.06 in CD patients and 466.48 in controls, with no statistically significant difference (p = 0.037). No correlation was observed between SII and autoantibody or genetic markers. Hemoglobin and platelet levels differed significantly between groups (p = 0.011 and p = 0.001). SII showed a strong positive correlation with ESR and hemoglobin, and a weak correlation with CRP. Conclusion: Although SII was higher in CD patients, it was not significantly associated with serological or genetic markers. SII may reflect systemic inflammation in CD beyond traditional markers. Further prospective studies are needed to clarify its role in diagnosis and monitoring.
Keywords : Çölyak hastalığı, inflamasyon, sistemik inflamatuvar indeks

ORIGINAL ARTICLE URL