The effect of Cynara scolymus L. on cardiac functions in rats with experimental cardiac injury induced by total circulatory arrest

Authors : Murat Ziya Bağış, Ezhar Ersöz, Bişar Amaç, İsmail Koyuncu, Muhammet Emin Güldür, Yasemin Hacanlı, Kadir Eği, Serdar Günaydın

Pages : 491-496

Doi:10.18663/tjcl.1767150

View : 68 | Download : 147

Publication Date : 2026-01-01

Article Type : Research Paper

Abstract :Objective: In this study, the potential protective effects of Cynara scolymus L. (CSL) extract on cardiac tissue and the underlying mechanisms mediating this effect were evaluated using a total circulatory arrest model in rats. Methods: A total of 24 adult male Wistar Albino rats were used in this study. The animals were randomly and equally divided into four groups (n=6): Group I (Sham), Group II (Total Circulatory Arrest – TSA), Group III [Treatment Group 1 (TSA + Cynara scolymus L. extract)], and Group IV [Treatment Group 2 (Cynara scolymus L. extract)]. After the completion of the experimental protocol, blood and cardiac tissue samples were collected from the animals. Biochemical analyses were performed to measure the levels of malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), creatine kinase-MB (CK-MB), troponin I, tumor necrosis factor-alpha (TNF-α), hypoxia-inducible factor 1-alpha (HIF-1α), and nuclear factor erythroid 2–related factor 2 (NRF2). Additionally, the harvested cardiac tissues were examined histopathologically to evaluate structural changes. Results: According to the findings, there were no statistically significant differences between the groups in terms of MDA (p=0.71), TOS (p=0.21), and OSI (p=0.45) levels. However, statistically significant differences were observed in TAS, TNF-α, HIF-1α, and NRF2 levels (p<0.01). Histopathological examination of the heart revealed that the treatment groups had fewer areas of focal necrosis compared to Group II. Conclusion: The findings of this study indicate that Cynara scolymus L. extract exhibits significant anti-inflammatory and antioxidant protective effects against ischemia-reperfusion-induced cardiac injury. These results support the potential of CSL extract as a cardioprotective agent. However, further studies are needed to elucidate the underlying molecular mechanisms of these protective effects in more detail.
Keywords : Cynara scolymus L. (CSL) ekstresi, Total Dolaşım Durması, Antioksidan, Tümör Nekroz Faktörü-alfa (TNF-α), Hipoksi ile indüklenebilir Faktör 1-alfa (HIF-1α), Nükleer Faktör Eritroid 2 ile ilişkili Faktör 2 (NRF2).

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