Serum sCD163 in patients with leukocytoclastic vasculitis and its relationship with various disease parameters

Authors : Mine Büşra Bozkürk, Gamze Tas Aygar
Pages : 505-513
Doi:10.18663/tjcl.1783351
View : 60 | Download : 100
Publication Date : 2026-01-01
Article Type : Research Paper
Abstract :Aim: This study aimed to investigate serum soluble CD163 (sCD163) levels in patients diagnosed with leukocytoclastic vasculitis (LCV) and evaluate the relationship between this biomarker and clinical, laboratory, and disease severity. Material and Methods: Forty-three patients with LCV and 45 healthy controls were included in our study. Serum sCD163 levels were measured using ELISA. The differences in sCD163 levels between groups, their correlation with disease, and the relationship between the findings and location were evaluated using ROC and multivariate analyses. Results: CRP, ESR, WBC, PLT, neutrophil count, BMI, and serum sCD163 levels were significantly higher in the LCV group than in the control group, whereas HGB and RBC levels were lower (p<0.05). sCD163 levels were positively correlated with CRP, ESR, and other inflammatory parameters and negatively correlated with HGB and RBC. ROC analysis revealed 100% sensitivity and specificity for the sCD163 marker, with an AUC of 1.00. However, logistic regression analysis did not identify sCD163 as a significant independent predictor. Multivariate PCA and PLS-DA analyses revealed a significant difference between the patient and control groups, with sCD163 being the most significant distinguishing variable. Conclusion: Our study revealed that serum sCD163 levels were significantly increased in patients with LCV and were strongly correlated with inflammatory activity. Although sCD163 alone is not sufficient to predict disease severity, its high diagnostic accuracy may make it a valuable biomarker for clinicians in the diagnosis of LCV. Our findings are consistent with data suggesting a role for macrophage activation in the pathogenesis of LCV disease.
Keywords : Biyobelirteç, CD163, inflamasyon, lökositoklastik vaskülit

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