Effects of neoadjuvant and adjuvant chemotherapy on survival in muscle-invasive bladder cancer: A multicenter study

Authors : Nargiz Majidova, Ahmet Emin Öztürk, Rumeysa Çolak, Özge Yalıcı, Mehmet Cihan İçli, Barış Köksal, Murat Arcagök, Sevdenur Taşkın, Yaprak Caglar, Ali Kaan Güren, Erkam Kocaaslan, Pınar Erel, Yeşim Ağyol, Nadiye Sever, Abdussamet Çelebi, Rukiye Arıkan, Selver Işık, Vedat Bayoğlu, Osman Köstek, Erdoğan Selçuk Şeber, Zuhat Urakçı, Murat Sarı

Pages : 123-130

Doi:10.18663/tjcl.1575691

View : 39 | Download : 27

Publication Date : 2025-03-25

Article Type : Research Paper

Abstract :Aim: Muscle-invasive bladder cancer requires systemic treatment due to its high risk of metastasis. However, studies comparing neoadjuvant and adjuvant therapy regimens are currently limited. Our goal in this study was to compare the treatment efficacy of patients receiving neoadjuvant or adjuvant treatment in locally advanced bladder cancer. Material and Methods: We retrospectively included 107 bladder cancer patients from 6 centres who underwent radical cystectomy and received perioperative chemotherapy. Patients were divided into 2 categories: (i) neoadjuvant chemotherapy (n=54) and (ii) adjuvant chemotherapy (n=53). Results: Median follow-up was 31.6 months (95%CI 21.8-41.4). 30-month disease-free survival (DFS) was 58.9% in the whole group, 56.3% in neoadjuvant and 61.5% in adjuvant. 30-month DFS after neoadjuvant treatment was 70.1% in Keywords : mesane kanseri, neoadjuvan kemoterapi, radikal sistektomi, adjuvan kemoterapi, sağkalım sonuçları

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