Is preoperative vitamin D level a risk factor for acute kidney injury developing after cardiopulmonary bypass?

Authors : Ersin ÇELİK, Ahmet ÇORA, Kadir Burhan KARADEM

Pages : 247-254

Doi:10.56150/tjhsl.1211890

View : 39 | Download : 12

Publication Date : 2022-12-30

Article Type : Research Paper

Abstract :Objective: In this study, the relationship between acute kidney injury insert ignore into journalissuearticles values(AKI); that developed in the early postoperative period in the patients that underwent open heart surgery with cardiopulmonary bypass insert ignore into journalissuearticles values(CPB); and their preoperative 25-Hydroxy Vitamin D insert ignore into journalissuearticles values(25-OHD); levels was investigated. Method: 285 patients who underwent open heart surgery with CPB between February 2018 and December 2020 were retrospectively analyzed. Ninety seven patients insert ignore into journalissuearticles values(71 men, 26 women); who met the criteria were included in the study. The patients were divided into 3 groups according to their preoperative 25-OHD levels as deficiency insert ignore into journalissuearticles values(group I, n=28);, insufficiency insert ignore into journalissuearticles values(group II, n=42); and normal insert ignore into journalissuearticles values(group III, n=27);.Demographic and clinical characteristics, AKI, and CPB time were compared between the groups.Kidney Disease: Improving Global Outcomes insert ignore into journalissuearticles values(KDIGO); guidelines were used to define postoperative AKI. Results: According to the KDIGO guidelines, the incidence of postoperative AKI decreased to 19% at the end of 48 hours and to 6.2% at discharge whereas it was 21% in the first 24 hours. The decrease in KDIGO AKI stages was found to be statistically significant insert ignore into journalissuearticles values(p=0.002);. The rate of DM was found to be significantly higher in Group I insert ignore into journalissuearticles values(p=0.001);. No statistical difference was found between AKI and 25-OHD levels at 24 hours, 48 hours and discharge. CPB time was found to be significantly higher in Group I insert ignore into journalissuearticles values(p=0.006);. In the univariate logistic regression model created after 25-OHD groups were taken as low insert ignore into journalissuearticles values(group I+group II); and normal insert ignore into journalissuearticles values(group III);, low 25-OHD levels were found to have a significant effect on the development of DM insert ignore into journalissuearticles values(p=0.001, OR:8.474, 95%CI 2.336 -30.303);. Conclusion: Although we could not find a statistical relationship between AKI and preoperative 25-OHD levels in the patients that underwent open heart surgery with CPB, we believe that 25-OHD deficiency might have effects on postoperative morbidity and mortality by affecting the renocardiovascular system.
Keywords : 25 Hydroxy Vitamin D, acute kidney injury, cardiopulmonary bypass, reninangiotensin system, diabetes mellitus

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