Determination of Oxidative Stress and Antioxidant Activities in Dogs Infected with Canine Distemper Virus

Authors : Durmuş HATİPOĞLU, Irmak DİK, Erdem GÜLERSOY

Pages : 67-70

Doi:10.36483/vanvetj.1136569

View : 39 | Download : 8

Publication Date : 2022-11-29

Article Type : Research Paper

Abstract :Supraphysiological reactive oxygen species insert ignore into journalissuearticles values(ROS); has been linked to a variety of diseases, including cancer, inflammation, and neurodegeneration. One of the diseases pathophysiologically associated with ROS accumulation is canine distemper insert ignore into journalissuearticles values(CD);. The purpose of this study was to compare lipid peroxidation and antioxidant biomarkers in dogs infected with canine distemper virus insert ignore into journalissuearticles values(CDV); to healthy dogs. The animals in this study consisted of a total of 20 dogs, 10 CDV-positive dogs insert ignore into journalissuearticles values(Trial group); aged 0–12 months of different breeds and sexes, and 10 healthy dogs insert ignore into journalissuearticles values(Control group); aged 0–12 months of different breeds and sexes. Thiobarbituric acid reactive substances insert ignore into journalissuearticles values(TBARS);, glutathione insert ignore into journalissuearticles values(GSH); and superoxide dismutase insert ignore into journalissuearticles values(SOD); were evaluated with commercially available enzyme-linked immunosorbent assay kits using serum samples. While the activities of GSH and SOD were statistically lower in CDV positive animals compared to healthy animals insert ignore into journalissuearticles values(p<0.05);, the level of TBARS was significantly higher insert ignore into journalissuearticles values(p<0.05);. In conclusion, current study findings that CDV increases lipid peroxidation activity in serum while decreasing antioxidant enzyme levels may be useful for future research.
Keywords : Antioksidanlar, canine distemper virüsü, Lipid peroxidation

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